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首页> 外文学位 >Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.
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Biodegradable unsaturated poly(ester-amide)s and their hydrogels: Synthesis, characterization, biodegradation and biomedical applications as drug carriers.

机译：可生物降解的不饱和聚（酯酰胺）及其水凝胶：合成，表征，生物降解和生物医学作为药物载体的应用。

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摘要

We first synthesized a group of novel biodegradable unsaturated poly(ester-amide)s (UPEAs) by solution polycondensation of two unsaturated monomers, di- p-nitrophenyl fumarate and L-phenylalanine 2-butene-1,4-diol diester p-toluene sulfonate, and four other saturated monomers of different combinations. The Tg's of UPEAs are higher than those of the saturated PEAS (SPEAs) having similar chemical structure, and affected more by the >C=C double bonds located in diamide part than by those in diester part of the UPEAs.; With the availability of the inherent >C=C double bonds in the UPEAs' backbone, a series of biodegradable UPEA/PEG-DA (UPEA-G) hydrogels was formulated from UPEA and poly(ethylene glycol) diacrylate (PEG-DA) by UV photocrosslinking. The incorporation of the hydrophobic UPEA into the hydrophilic PEG-DA hydrogels increased their hydrophobicity, crosslinking density and mechanical strength, but reduced equilibrium swelling ratio (Qeq). When different types of UPEA were coupled with PEG-DA at the same feed ratio (20 wt%), the resultant hydrogels had similar Qeq and porous three-dimensional interior morphology, but different gel fraction (Gf) and compressive modulus. These differences in hydrogel property were correlated to the chemical structure of the UPEA precursors, i.e., different location of >C=C double bonds in individual UPEA segments resulted in their different reactivity toward PEG-DA to form hydrogels.; The six-day biodegradation kinetics of UPEAs and UPEAs in both PBS buffer and alpha-chymotrypsin solution had been observed and their biodegradabilities were evaluated by weight loss. The effect of >C=C double bonds on the UPEAs' biodegradabilities were investigated and discussed. As for biodegradable UPEA-G hydrogels, their biodegradability had been studied in both pure PBS buffer and alpha-chymotrypsin solution for two months. It is found that the biodegradability of UPEA-G hydrogels can be controlled by the concentration of alpha-chymotrypsin in the biodegradation media, the type of UPEA precursor, and the precursors' feed ratio.; When one of these biodegradable hydrogels, FPBe-G, was used as the carrier for hydrophobic drugs, indomethacin (IDM) and paclitaxel, the drug release profiles could be controlled by the hydrogels precursor feed ratio, the biodegradation rate of hydrogels and the pore sizes of hydrogels. The sustained paclitaxel release without obvious initial burst effect over the two-month period was achieved.
机译：我们首先通过两种不饱和单体富马酸酯二对硝基苯基富马酸酯和L-苯丙氨酸2-丁烯-1,4-二醇二酯对甲苯的溶液缩聚合成了一组新型的可生物降解的不饱和聚（酯酰胺）（UPEA）。磺酸盐和其他四种不同组合的饱和单体。 UPEA的Tg高于化学结构相似的饱和PEAS（SPEA），而受二酰胺部分中> C = C <双键的影响比受UPEA的二酯部分的影响更大。借助UPEA骨架中固有的> C = C <双键，可以从UPEA和聚乙二醇二丙烯酸酯（PEG-DA）配制出一系列可生物降解的UPEA / PEG-DA（UPEA-G）水凝胶。通过紫外光交联。将疏水性UPEA掺入亲水性PEG-DA水凝胶可提高其疏水性，交联密度和机械强度，但降低了平衡溶胀率（Qeq）。当以相同的进料比（20 wt％）将不同类型的UPEA与PEG-DA偶联时，所得水凝胶具有相似的Qeq和多孔三维内部形态，但凝胶分数（Gf）和压缩模量却不同。水凝胶性质的这些差异与UPEA前体的化学结构相关，即，各个UPEA片段中> C = C <双键的不同位置导致它们对PEG-DA的反应性不同，从而形成水凝胶。在PBS缓冲液和α-胰凝乳蛋白酶溶液中均观察到UPEA和UPEA的六天生物降解动力学，并通过失重评估其生物降解性。研究并讨论了> C = C <双键对UPEAs生物降解性的影响。对于可生物降解的UPEA-G水凝胶，已经在纯PBS缓冲液和α-胰凝乳蛋白酶溶液中研究了其生物降解能力两个月。已经发现，UPEA-G水凝胶的生物降解性可以通过生物降解介质中α-胰凝乳蛋白酶的浓度，UPEA前体的类型和前体的进料比来控制。当将其中一种可生物降解的水凝胶FPBe-G用作疏水性药物吲哚美辛（IDM）和紫杉醇的载体时，药物释放曲线可以通过水凝胶前体进料比，水凝胶的生物降解率和孔径来控制水凝胶。在两个月的时间内，紫杉醇得以持续释放而没有明显的初期爆发效应。

著录项

  • 作者

    Guo, Kai.;

  • 作者单位

    Cornell University.;

  • 授予单位 Cornell University.;
  • 学科 Chemistry Polymer.; Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 157 p.
  • 总页数 157
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化学（高聚物）;生物医学工程;
  • 关键词

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