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首页> 外文学位 >Effect of acute lung volume reduction surgery on lung mechanics and maximal flow in a canine model of upper lobe emphysema.
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Effect of acute lung volume reduction surgery on lung mechanics and maximal flow in a canine model of upper lobe emphysema.

机译：急性肺减容术对上肺气肿犬模型肺力学和最大流量的影响。

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摘要

In severe pulmonary emphysema, lung volume reduction surgery (LVRS) is a palliative surgical procedure that has been shown to improve lung function and maximal expiratory flow in selected patients. However, in the immediate perioperative period, the acute physiologic changes following LVRS are not fully understood and may represent a period of potentially high morbidity. The changes in parameters of maximal expiratory flow limitation that occur immediately following lung volume reduction surgery in a canine model of upper lobe emphysema were investigated in this study.; Healthy dogs were randomized to undergo development of bilateral upper lobe emphysema (n=9) through repeated bronchoscopic instillations of the proteolytic enzyme papain or to serve as healthy controls (n=8). Satisfactory development of emphysema was confirmed by measuring lung volumes at baseline and after serial papain administration and noting an increase in total lung capacity (TLC) to 120% of the pre-emphysema value. Dogs with and without emphysema were then randomized to have LVRS or to serve in time control groups. (Abstract shortened by UMI.)
机译：在严重的肺气肿中，肺减容术（LVRS）是一种姑息性外科手术，已显示可改善所选患者的肺功能和最大呼气流量。但是，在围手术期的近期，尚未完全了解LVRS后的急性生理变化，可能代表了一段潜在的高发病率。在这项研究中，研究了上肺气肿犬模型中肺减容手术后立即发生的最大呼气流量限制参数的变化。通过重复支气管镜下注入蛋白水解酶木瓜蛋白酶将健康犬随机分为双侧上叶气肿（n = 9）或作为健康对照（n = 8）。通过测量基线和连续给予木瓜蛋白酶后的肺容量并注意到总肺活量（TLC）增加至肺气肿前值的120％，可以确定肺气肿的令人满意的发展。然后将有或没有肺气肿的狗随机分为LVRS组或时间对照组。 （摘要由UMI缩短。）

著录项

  • 作者

    Buduhan, Gordon.;

  • 作者单位

    University of Manitoba (Canada).;

  • 授予单位 University of Manitoba (Canada).;
  • 学科 Health Sciences Medicine and Surgery.; Health Sciences Pathology.
  • 学位 M.Sc.
  • 年度 2005
  • 页码 74 p.
  • 总页数 74
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 病理学;
  • 关键词

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