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首页> 外文学位 >Two formulations of the industrial surfactant, Toximul, differentially reduce hepatic glycogen in a surfactant/influenza B virus mouse model of acute liver failure: Correlations with effects on HepG2 glycogen content.
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Two formulations of the industrial surfactant, Toximul, differentially reduce hepatic glycogen in a surfactant/influenza B virus mouse model of acute liver failure: Correlations with effects on HepG2 glycogen content.

机译：在急性肝衰竭的表面活性剂/ B型流感病毒小鼠模型中，两种工业表面活性剂Toximul可以差异地减少肝糖原：与HepG2糖原含量影响的相关性。

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摘要

Industrial surfactants (ISs) are used extensively in the environment to suspend water immiscible chemicals, such as pesticides. Many of them are labeled as biologically inert. However, young mice exposed chronically to the industrial surfactant Toximul (Tox) and subsequently infected with influenza B virus (FluB) exhibit many of the symptoms of acute liver failure. Recently, Tox exposure has been shown to result in significant reduction in mouse liver glycogen several days after exposure to Tox had ceased. The time course of Tox effects on hepatic glycogen has not been investigated previously. The first study was designed to characterize and compare the effects of two formulations of Tox (Tox 3409F and Tox MP-A) without and with FluB on liver glycogen content and body weights from birth to postnatal day (P) 21 in CFW and CD-1 mice. The second study was designed to investigate the effects of Tox 3409F and Tox MP-A (concentration- and time-dependence) on the human hepatoma HepG2 cell-line. (Abstract shortened by UMI.)
机译：工业表面活性剂（ISs）在环境中广泛用于悬浮与水不混溶的化学物质，例如农药。其中许多被标记为生物学惰性的。但是，长期暴露于工业表面活性剂Toximul（Tox）并随后感染了B型流感病毒（FluB）的年轻小鼠表现出许多急性肝衰竭的症状。最近，已证明在停止暴露于Tox数天后，Tox暴露会导致小鼠肝糖原的显着减少。毒物对肝糖原的影响的时程以前没有研究过。第一项研究旨在表征和比较两种不含或含FluB的Tox制剂（Tox 3409F和Tox MP-A）对CFW和CD-从出生到出生后第21天的肝糖原含量和体重的影响。 1只小鼠。第二项研究旨在研究Tox 3409F和Tox MP-A（浓度和时间依赖性）对人肝癌HepG2细胞系的影响。 （摘要由UMI缩短。）

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  • 作者

    Al-Khalidi, Mustafa.;

  • 作者单位

    Dalhousie University (Canada).;

  • 授予单位 Dalhousie University (Canada).;
  • 学科 Health Sciences Toxicology.; Chemistry Biochemistry.
  • 学位 M.Sc.
  • 年度 2005
  • 页码 145 p.
  • 总页数 145
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 毒物学（毒理学）;生物化学;
  • 关键词

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