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首页> 外文学位 >Perspectives on alcohol toxicity in medaka embryogenesis and possible protection by Asian ginseng (Panax ginseng): Histological and biochemical analysis.
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Perspectives on alcohol toxicity in medaka embryogenesis and possible protection by Asian ginseng (Panax ginseng): Histological and biochemical analysis.

机译：在人参胚胎发生中酒精毒性的观点以及亚洲人参（Panax ginseng）可能的保护作用：组织学和生化分析。

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摘要

Alcohol is recognized as a classic teratogen capable of inducing a wide range of developmental abnormalities. Alcohol consumption during pregnancy may produce permanent brain damage in the fetus and is associated with the development of a life-long behavioral, social, and cognitive disorder now known as fetal alcohol spectrum disorder (FASD). The most clinically recognizable form of FASD is fetal alcohol syndrome (FAS) which is characterized by specific features including facial dysmorphogenesis, mental dysfunction, growth retardation, and cardiovascular and limb defects. Due to ethical constraints, human studies of FASD are very limited. Therefore our current understanding of FASD is mainly based on several animal models (vertebrate and invertebrate). The fish embryo, especially zebrafish (Danio rerio) and Japanese medaka ( Oryzias latipes), are long-established models for research in developmental biology and have been used to explore alcohol's effect on neurogenesis, cardiogenesis, intracellular signaling, neurobehavioral aspects, and apoptosis. These two fish models have proven utility for studying alcohol's damaging effects during morphogenesis. In this study we have demonstrated that exposing Japanese medaka embryos to alcohol during development showed phenotypic features and biochemical parameters that are comparable to FASD phenotypes observed in humans.;Asian ginseng (PG) root extract has been shown to have anti alcoholic activities in a number of studies. In this study we have used medaka embryos to induce FASD like neurological defects. We have also investigated the ability of Asian ginseng (PG) to function as a preventive agent of these defects. Our findings suggest that medaka embryogenesis, can be a very useful model for investigating the molecular and morphological endpoints of FASD, and that PG root extract has a protective effect against alcohol induced toxicity in medaka embryogenesis.
机译：酒精被公认为是经典的致畸剂，能够引起广泛的发育异常。怀孕期间饮酒可能会对胎儿造成永久性脑损伤，并与终生的行为，社交和认知障碍（现称为胎儿酒精频谱障碍（FASD））的发展有关。 FASD的临床上最易识别的形式是胎儿酒精综合症（FAS），其特征为特定特征，包括面部畸形发生，精神功能障碍，发育迟缓以及心血管和四肢缺陷。由于伦理上的限制，对FASD的人类研究非常有限。因此，我们对FASD的当前理解主要基于几种动物模型（脊椎动物和无脊椎动物）。鱼胚，特别是斑马鱼（Danio rerio）和日本（Oryzias latipes），是发展生物学研究的长期建立的模型，已被用于研究酒精对神经发生，心脏发生，细胞内信号转导，神经行为和凋亡的影响。这两种鱼模型已被证明可用于研究形态发生过程中酒精的破坏作用。在这项研究中，我们证明了在发育过程中将日本高胚胎暴露于酒精中，其表型特征和生化参数与人类观察到的FASD表型相当;亚洲人参（PG）根提取物已被证明具有抗酒精活性研究。在这项研究中，我们使用了高aka胚胎来诱导FASD样神经系统缺陷。我们还研究了人参（PG）用作预防这些缺陷的作用。我们的发现表明，花aka胚胎发生可能是研究FASD分子和形态学终点的非常有用的模型，而PG根提取物具有抗酒精诱导的花aka胚发生毒性的保护作用。

著录项

  • 作者

    Haron, Mona H.;

  • 作者单位

    The University of Mississippi.;

  • 授予单位 The University of Mississippi.;
  • 学科 Pharmacology.
  • 学位 Ph.D.
  • 年度 2013
  • 页码 152 p.
  • 总页数 152
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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