• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Enabling Studies to Optimize Biomaterials for the Treatment of Myocardial Infarction.
【24h】

Enabling Studies to Optimize Biomaterials for the Treatment of Myocardial Infarction.

机译：使研究最优化用于治疗心肌梗塞的生物材料的研究。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The canonical mechanism of wound healing is disrupted following a myocardial infarction (MI), manifesting as an unregulated response that negatively impacts left ventricular (LV) function. This mechanism, termed post-MI remodeling, culminates in an outcome that favors progression to a systolic heart failure state and death for the patient. Therapeutic approaches following the occurrence of a MI are designed to modulate the natural remodeling process and mitigate the loss of cardiac function. The mechanics and structure of the healing infarct have been the focus of numerous pre-clinical and clinical investigations, leading to the impending clinical introduction of material injections as a means to favorably alter remodeling outcomes. However, to date there is no body of work that provides a coherent framework for evaluation of targeted material therapies. To form a basis for optimization of material-based MI treatments, we have integrated measurements of MI regional mechanics, the morphology of the local extracellular matrix, and the biophysical impact of material injections into the MI region in a porcine model of MI. The combined findings of this study have enhanced a mechanistic understanding of material-based post-MI interventions, elucidated the relationship between MI regional mechanics and LV function throughout the natural and attenuated history of LV remodeling, and has developed mechanical metrics of value to move forth towards future developments of a generalizable computational tools for screening and evaluation of new strategies for MI injections.
机译：心肌梗塞（MI）后，伤口愈合的规范机制被破坏，表现为对左心室（LV）功能产生负面影响的不受调节的反应。这种机制被称为心梗后重塑，最终达到有利于进展为收缩性心力衰竭状态和患者死亡的结果。 MI发生后的治疗方法旨在调节自然重塑过程并减轻心脏功能的丧失。愈合性梗塞的力学和结构一直是许多临床前和临床研究的重点，导致迫切需要将材料注射用于临床，从而有利地改变重塑结果。但是，迄今为止，尚无任何工作可为评估靶向材料疗法提供一致的框架。为了形成优化基于材料的心肌梗死治疗的基础，我们对MI的猪模型中的MI区域力学，局部细胞外基质的形态以及材料注入MI区域的生物物理影响进行了综合测量。这项研究的综合发现增强了对基于材料的MI后干预的机械理解，阐明了在LV重塑的自然和减弱的历史过程中MI区域力学与LV功能之间的关系，并开发了继续前进的力学指标面向可筛选和评估MI注射新策略的通用计算工具的未来发展。

著录项

  • 作者

    Romito, Eva Adriana.;

  • 作者单位

    University of South Carolina.;

  • 授予单位 University of South Carolina.;
  • 学科 Biomedical engineering.;Materials science.;Biomechanics.
  • 学位 Ph.D.
  • 年度 2016
  • 页码 130 p.
  • 总页数 130
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号