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首页> 外文学位 >Reproducibility of Exercise Testing in Patients with Pulmonary Arteriovenous Malformations.
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Reproducibility of Exercise Testing in Patients with Pulmonary Arteriovenous Malformations.

机译：肺动静脉畸形患者运动测试的可重复性。

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摘要

Patients with pulmonary arteriovenous malformations (PAVMs) are at risk for complications, hemorrhagic and neurological, and therefore require close follow-up.;The primary hypothesis of this project poses that the exercise stress test (EST) and 6-minute walk test (6MWT) are reproducible and reliable in patients with PAVMs. Secondarily, if these tests are shown to be reproducible, they may become a surrogate follow-up tool for patients with PAVMs after quantification with non-contrast CT and may replace contrast echocardiography in asymptomatic children under age 12.;Twenty-two patients with PAVMs, most of whom had hereditary hemorrhagic telangiectasia (HHT), participated in a Human Investigations Committee-approved protocol. Patients ranged from 9 to 74 years of age (mean 28) and had a broad spectrum of anatomic subtypes of PAVMs, including focal and diffuse. Standard 6MWT and cycle ergometry EST were both performed twice with adequate rest between tests. Heart rate (HR) and oxygen saturation were measured at the beginning and end of each test. Distance walked and maximum resistance were also recorded. The intraclass correlation coefficients (ri) at the end of 6MWT were as follows: HR (ri = 0.940; 95% CI = 0.863-0.975), post test oxygen saturations (ri = 0.973; 95% CI = 0.933-0.989), distance walked (ri = 0.942; 95% CI = 0.867-0.975). The r is at the end of EST were as follows: HR (ri = 0.941; 95% CI 0.865-0.975), oxygen saturation (ri = 0.993; 95% CI 0.982-0.997), and maximum resistance (ri = 0.941; 95% CI 0.864-0.975). 6MWT and EST were reproducible measures of exercise capacity and oxygen saturation and are potential adjunct tests in the follow-up assessment for patients with PAVMs.
机译：肺动静脉畸形（PAVM）的患者有发生并发症，出血和神经​​系统疾病的风险，因此需要密切随访。;该项目的主要假设是运动压力测试（EST）和6分钟步行测试（6MWT） ）在PAVM患者中可重现且可靠。其次，如果显示这些测试具有可重复性，则在用非对比CT定量后，它们可能成为PAVM患者的替代随访工具，并可以替代12岁以下无症状儿童的超声心动图检查； 22例PAVM患者，其中大多数患有遗传性出血性毛细血管扩张（HHT），他们参加了人类调查委员会批准的协议。患者年龄在9至74岁之间（平均28岁），具有广泛的PAVM解剖亚型，包括局灶性和弥散性。标准的6MWT和循环测功法EST均进行了两次，两次测试之间要有足够的休息时间。在每次测试的开始和结束时都要测量心率（HR）和血氧饱和度。还记录了步行距离和最大阻力。 6MWT结束时的组内相关系数（ri）如下：HR（ri = 0.940; 95％CI = 0.863-0.975），测试后氧饱和度（ri = 0.973; 95％CI = 0.933-0.989），距离行走（ri = 0.942; 95％CI = 0.867-0.975）。 EST结束时的r如下：HR（ri = 0.941; 95％CI 0.865-0.975），氧饱和度（ri = 0.993; 95％CI 0.982-0.997）和最大电阻（ri = 0.941; 95） ％CI 0.864-0.975）。 6MWT和EST是运动能力和血氧饱和度的可重复测量，是PAVM患者随访评估中的潜在辅助测试。

著录项

  • 作者

    Niu, Bolin.;

  • 作者单位

    Yale University.;

  • 授予单位 Yale University.;
  • 学科 Health Sciences Medicine and Surgery.;Health Sciences Radiology.
  • 学位 M.D.
  • 年度 2012
  • 页码 55 p.
  • 总页数 55
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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