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首页> 外文学位 >Synthesis and characterization of collagen methacrylamide sponges for use as a biological scaffold.
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Synthesis and characterization of collagen methacrylamide sponges for use as a biological scaffold.

机译：用作生物支架的甲基丙烯酸甲酯胶原蛋白海绵的合成和表征。

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摘要

The goal of this thesis was to develop collagen methacrylamide (CMA) into a functional biological scaffold by enhancing its physical strength. CMA is a biocompatible, functionalized type I collagen moiety whose physical strength can be modulated by UV light exposure. Commercially-available, collagen-based biological devices comprised of decellularized ECM possess excellent mechanical properties, but are limited in their amenability to physical and chemical patterning. Scaffolds manufactured from purified collagens are not suitable for most biomedical applications because of their limited physical strength. In the first study, collagen methacrylamide was processed into sponges by lyophilization. Subsequently, the material was characterized through rheometry and found to be weaker than its corresponding hydrogel. A second study evaluated increasing the concentration of the material to increase its strength. In a third study, EDC crosslinking was employed as an additional method to increase the strength of CMA. Both studies demonstrated an increase in the tensile strength and elastic modulus of CMA sponges. However, further increases in strength will be necessary in order for this device to be feasible as a biological scaffold. Nevertheless, the potential exists for CMA sponges, containing gradients of stiffness or peptide-patterning, to be developed into a superior material for numerous tissue engineering applications.
机译：本文的目的是通过增强其物理强度，将甲基丙烯酸丙烯酰胺（CMA）发展成为一种功能性生物支架。 CMA是生物相容的功能化的I型胶原蛋白部分，其物理强度可以通过紫外线照射来调节。由脱细胞的ECM组成的可商购的基于胶原的生物装置具有优异的机械性能，但是其对物理和化学图案的适应性受到限制。由纯化的胶原蛋白制成的支架由于其有限的物理强度而不适用于大多数生物医学应用。在第一个研究中，通过冻干将甲基丙烯酸胶原蛋白加工成海绵。随后，通过流变法对该材料进行了表征，发现该材料比其相应的水凝胶弱。第二项研究评估了增加材料的浓度以增加其强度。在第三项研究中，采用EDC交联作为增加CMA强度的另一种方法。两项研究均表明CMA海绵的拉伸强度和弹性模量有所提高。然而，强度的进一步增加将是必要的，以使该装置作为生物支架是可行的。尽管如此，包含CMA海绵的硬度（包含刚度梯度或肽图样的梯度）存在潜力，可以被开发成用于众多组织工程应用的优质材料。

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  • 作者

    Branch, Jonathan Richard.;

  • 作者单位

    Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey.;

  • 授予单位 Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey.;
  • 学科 Engineering Biomedical.
  • 学位 M.S.
  • 年度 2012
  • 页码 122 p.
  • 总页数 122
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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