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Using GIS methods to assess the occurrence of neural tube defect births by residential proximity at conception to hazardous waste sites.

机译：使用GIS方法通过居民接近危险废物场所来评估神经管缺陷出生的发生。

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摘要

In the United States, approximately 4,000 pregnancies each year are affected by the two most common birth defects, spina bifida and anencephaly. Studies have shown that exposure to environmental chemicals before and after conception may adversely affect reproduction by inducing cell death or dysfunction, which leads to infertility, fetal loss, lowered weight at birth, or birth anomalies in the offspring. The objective of the study was to evaluate the relationship between Neural Tube Defect births and residence at conception in proximity to hazardous waste sites in the Texas-Mexico border region between 1993 and 2000.; The study design was a nested matched case-control and utilized secondary data from a project, "The role of chemical and biological factors in the etiology of neural tube birth defects births along the Texas-Mexico Border" (Irina Cech, Principal Investigator). Geographic Information Systems (GIS) database methods were used to compare Neural Tube Defects cases to controls on status of conception residence occurring within a one-mile radius from hazardous waste sites, as compared to conception residence further away. Information on the exposures was obtained from the OnTarget Database and Environment Protection Agency website. Conditional logistic regression was used for the matched case-control study to investigate the relationship between an outcome of being a case or a control and proximity to hazardous waste sites.; The result of the study showed a 36 percent non-significant increased risk of having an NTD birth associated with maternal proximity to abandoned hazardous waste sites (95% CI = 0.62--3.02). In addition, there was a 24% non-significant elevated risk of having an NTD birth when living in proximity to air pollutant sites than when living further away (95% CI = 0.67--2.32). Although this study did not find statistically significant associations, it will expand on the existing knowledge of the relationship between NTD and proximity to hazardous waste sites.
机译：在美国，每年约有4,000次怀孕受到脊柱裂和无脑畸形这两种最常见的出生缺陷的影响。研究表明，受孕前后接触环境化学物质可能会导致细胞死亡或功能障碍，从而对生殖能力产生不利影响，从而导致不育，胎儿流产，出生时体重减轻或后代出生畸形。该研究的目的是评估1993年至2000年在得克萨斯州-墨西哥边境地区危险废物场所附近的神经管畸形出生与受孕居住之间的关系。该研究设计是嵌套的匹配病例对照，并利用了一个项目的次要数据，即“化学和生物学因素在德克萨斯-墨西哥边境沿神经管先天缺陷出生的病因中的作用”（首席研究员Irina Cech）。地理信息系统（GIS）数据库方法用于比较“神经管缺陷”病例与距危险废物场所一英里半径范围内发生的概念性居留状态的控制情况（与距离更远的概念性居所相比）。有关暴露的信息可从OnTarget数据库和环境保护局的网站获得。有条件的逻辑回归被用于匹配的病例对照研究，以调查作为病例或对照的结果与危险废物场所附近之间的关系。研究结果表明，与母亲接近废弃危险废物场所相关的NTD出生风险显着增加了36％（95％CI = 0.62--3.02）。此外，与空气污染较近的地区居住相比，NTD出生的危险性显着增加24％（95％CI = 0.67--2.32）。尽管该研究没有发现统计学上的显着关联，但它将在现有NTD与危险废物场所附近的关系的知识上进行扩展。

著录项

  • 作者

    Al-Hashimi, Radhiya Yahya.;

  • 作者单位

    The University of Texas School of Public Health.;

  • 授予单位 The University of Texas School of Public Health.;
  • 学科 Health Sciences Public Health.; Environmental Sciences.
  • 学位 Dr.P.H.
  • 年度 2005
  • 页码 195 p.
  • 总页数 195
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;环境科学基础理论;
  • 关键词

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