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Acute Salmonella infection in swine.

机译：猪急性沙门氏菌感染。

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摘要

The objectives of this dissertation are focused on defining acute Salmonella infection in swine, and contains six chapters and two appendices. Acute Salmonella infection is defined as the ability of swine to infect alimentary and non-alimentary tissues within 3 hours following inoculation.; Chapter 1 provides a general overview of Salmonella. It includes a description of swine salmonellosis, the pig's response to Salmonella infection, methods of Salmonella detection, an overview of intervention used for the reduction of Salmonella infections, and describes acute Salmonella infection in swine.; Chapter 2 indicates that the most common swine associated Salmonella serotypes are capable of acutely infecting pigs. Pigs were inoculated with varying Salmonella serotypes, necropsied, and alimentary and non-alimentary tissues were cultured for the presence of Salmonella . In conclusion, Salmonella wildtype isolates were capable of acutely infecting pigs more so than vaccine strains.; Chapter 3 helps elucidate the mechanisms utilized by Salmonella to acutely infect swine. Varying Salmonella wildtype isolates, mutant strains, and vaccine strains were inoculated and evaluated in there abilities to acutely infect pigs. Reduction in acute Salmonella infection was seen in avirulent deletion mutants in which the cya/crp genes had been inactivated or in those strains attenuated by neutrophil passage. This study also indicated that acute infection virulence may be enhanced after continual passage of Salmonella through pigs.; Chapter 4 indicates the minimal number of Salmonella that are required to induce acute Salmonella infection. Pigs were exposed to various levels of Salmonella by either intranasal inoculation, or subjecting them to a contaminated environment. Greater than 1 X 103 Salmonellae were required to induce acute Salmonella infection.; Chapter 5 analyzes acute Salmonella infection in germfree pigs. Germfree pigs were inoculated with probiotic bacteria and subsequently challenged with Salmonella. This study established a germfree probiotic model for the reduction of acute Salmonella infection, and indicates that germfree pigs are susceptible to acute Salmonella infection.; Chapter 6 is a general conclusions chapter. Additionally, it provides suggestions for further work to advance science in the field of acute Salmonella infection in swine.
机译：本文的研究重点是确定猪的急性沙门氏菌感染，共分为六章和两个附录。急性沙门氏菌感染是指猪在接种后3小时内感染消化和非消化组织的能力。第1章概述了沙门氏菌。其中包括猪沙门氏菌病的描述，猪对沙门氏菌感染的反应，沙门氏菌的检测方法，减少沙门氏菌感染的干预措施概述，以及猪的急性沙门氏菌感染。第2章指出，最常见的与猪相关的沙门氏菌血清型能够急性感染猪。猪接种了不同的沙门氏菌血清型，进行了尸检，并培养了消化性和非消化性组织以检测沙门氏菌的存在。总之，沙门氏菌野生型分离株比疫苗株更能急性感染猪。第3章有助于阐明沙门氏菌对猪的急性感染机制。接种了各种沙门氏菌野生型分离株，突变株和疫苗株，并评估了它们对猪的急性感染能力。在其中cya / crp基因已失活的无毒缺失突变株或中性粒细胞传代减弱的菌株中，急性沙门氏菌感染有所减少。这项研究还表明，沙门氏菌不断通过猪后，急性感染的毒性可能会增强。第4章介绍了诱导急性沙门氏菌感染所需的沙门氏菌最少数量。通过鼻内接种或使其受到污染的环境使猪暴露于不同水平的沙门氏菌。诱导沙门氏菌急性感染需要大于1 X 103沙门氏菌。第5章分析了无菌猪的急性沙门氏菌感染。给无病猪接种益生菌，然后用沙门氏菌攻击。这项研究建立了减少急性沙门氏菌感染的无菌益生菌模型，并表明无菌猪对沙门氏菌急性感染很敏感。第6章是一般性结论章节。此外，它为进一步开展猪急性沙门氏菌感染研究提供了建议。

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  • 作者

    Loynachan, Alan Thomas.;

  • 作者单位

    Iowa State University.;

  • 授予单位 Iowa State University.;
  • 学科 Biology Microbiology.; Agriculture Animal Pathology.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 95 p.
  • 总页数 95
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;动物医学（兽医学）;
  • 关键词

  • 入库时间 2022-08-17 11:42:32

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