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首页> 外文学位 >Raman spectroscopy and diffuse reflectance spectroscopy for diagnosis of human cancer and acanthosis nigricans.
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Raman spectroscopy and diffuse reflectance spectroscopy for diagnosis of human cancer and acanthosis nigricans.

机译：拉曼光谱和漫反射光谱法可用于诊断人类癌症和黑棘皮病。

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摘要

Cancer and diabetes are common chronic diseases in today's world causing numerous deaths in adults as well as children. Most common types of cancers in adults include prostate, lung, breast, colorectal and head and neck squamous cell carcinoma, while among children; leukemia, and brain and central nervous system cancers are quite common. In each of these cases, early detection of the cancer or disease dramatically increases the chances of successful treatment. In recent years, there has been much interest in using Raman spectroscopy and diffuse reflectance spectroscopy as analytical optical spectroscopic methods for early diagnosis of diseases. Raman spectroscopy can be used to measure changes in the bio-molecular composition of a tissue specimen, and diffuse reflectance spectroscopy can measure chromophores of the skin. In this research, archived (formalin-fixed paraffin processed) tissues of head and neck squamous cell carcinoma, prostate, and pediatric tumors have been investigated using Raman spectroscopy. We have utilized statistical methods such as principal component analysis (PCA) and discriminant function analysis (DFA) to analyze the spectral output and distinguish between normal and cancerous tissues. The results show cancerous tissues can be successfully distinguished from normal tissues in three cancer types in ex vivo. However, due to loss of biochemical in the tissue processing (paraffinizing and deparaffinizing procedure), the prediction ability of the archived tissues are less compared to frozen tissues as observed in the pediatric tumor investigation.;We also investigated the diagnostic capability of diffuse reflectance spectroscopy and colorimetry on a skin disease, acanthosis nigricans in vivo. The aim is to quantify and characterize the skin color change associated with acanthosis nigricans skin disease in insulin-resistant obese individuals. We observe both the instruments can be utilized to detect acanthosis nigricans with more than 87% sensitivity and 94% specificity when combined with advanced chemometric methods.
机译：癌症和糖尿病是当今世界上常见的慢性疾病，导致成人和儿童大量死亡。成人中最常见的癌症类型包括儿童中的前列腺癌，肺癌，乳腺癌，结直肠癌和头颈部鳞状细胞癌。白血病以及脑和中枢神经系统癌症非常普遍。在每种情况下，早期发现癌症或疾病都会大大增加成功治疗的机会。近年来，使用拉曼光谱和漫反射光谱作为分析光学光谱法来疾病的早期诊断引起了人们的极大兴趣。拉曼光谱法可用于测量组织样本的生物分子组成的变化，而漫反射光谱法可用于测量皮肤的发色团。在这项研究中，已使用拉曼光谱法研究了头颈鳞状细胞癌，前列腺癌和小儿肿瘤的存档（经福尔马林固定的石蜡处理）组织。我们已经利用统计方法（例如主成分分析（PCA）和判别函数分析（DFA））来分析频谱输出并区分正常组织和癌变组织。结果表明，在三种活体内，癌组织可以成功地与正常组织区分开。然而，由于在组织处理（石蜡和去石蜡的过程）中生化物质的损失，与儿科肿瘤研究中观察到的冷冻组织相比，存档组织的预测能力较冷冻组织要差。；我们还研究了漫反射光谱的诊断能力和比色法对皮肤疾病，黑棘皮病体内。目的是量化和表征胰岛素抵抗性肥胖个体中与黑棘皮病皮肤病相关的皮肤颜色变化。我们观察到，与先进的化学计量学方法结合使用时，这两种仪器均可用于检测黑棘皮病，灵敏度超过87％，特异性达94％。

著录项

  • 作者

    Devpura, Suneetha.;

  • 作者单位

    Wayne State University.;

  • 授予单位 Wayne State University.;
  • 学科 Engineering Biomedical.;Biophysics Medical.;Physics Condensed Matter.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 177 p.
  • 总页数 177
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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