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Prevalence of Heavy Prenatal Alcohol Exposure in Uganda via Analysis of Fatty Acid Ethyl Esters in Meconium.

机译:通过分析胎粪中的脂肪酸乙基酯,分析乌干达产前重度酒精暴露的发生率。

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摘要

Fetal alcohol spectrum disorder (FASD) manifests as a continuum of permanent birth defects and neurodevelopmental impairments that originate from maternal alcohol use during pregnancy. The number of recognized FASD cases in parts of Sub-Saharan Africa is growing, which is a cause for concern. Prenatal alcohol exposure was examined via regional hospital population-based collection of meconium, and analysis of the fatty acid ethyl esters (FAEEs) contained within. Meconium samples were collected from five hundred ten neonates over a two-month period at Mbarara Regional Referral Hospital. Each meconium sample was accompanied by a maternal questionnaire. The prevalence of prenatal alcohol exposure using the maternal questionnaire was 16.1% (81 of 510). The overall prevalence of prenatal alcohol exposure via FAEE-meconium analysis in this population was 1.6% (8 of 510). This is the first population-based study of an entire local neonatal population examining fetal alcohol exposure via meconium-FAEE analysis conducted in Uganda.
机译:胎儿酒精频谱障碍(FASD)表现为永久性出生缺陷和神经发育障碍的连续体,这些缺陷源于怀孕期间孕妇饮酒。撒哈拉以南非洲部分地区公认的FASD案件数量在增加,这令人担忧。通过基于地区医院人群的胎粪收集并分析其中所含的脂肪酸乙酯(FAEE),检查了产前酒精暴露。在两个月的时间里,从姆巴拉拉地区转诊医院收集了510例新生儿的胎粪样本。每个胎粪样本均附有产妇问卷。使用产妇问卷调查的产前酒精暴露患病率为16.1%(510中的81)。通过FAEE-Meconium分析,该人群中产前酒精暴露的总体患病率为1.6%(510中的8)。这是在乌干达进行的通过胎粪-FAEE分析检查胎儿酒精暴露的整个本地新生儿的首次基于人群的研究。

著录项

  • 作者

    Nightingale, Ira Justin.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Pharmaceutical sciences.;Toxicology.
  • 学位 M.Sc.
  • 年度 2016
  • 页码 129 p.
  • 总页数 129
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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