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首页> 外文学位 >Temperature dependence of photoreceptor neuromodulation: Octopamine and Substance P modulate the duration and speed of sensory signals in the lateral eye of Limulus.
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Temperature dependence of photoreceptor neuromodulation: Octopamine and Substance P modulate the duration and speed of sensory signals in the lateral eye of Limulus.

机译：感光神经调节的温度依赖性：章鱼碱和P物质调节Li侧眼感觉信号的持续时间和速度。

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摘要

An endogenous circadian clock that releases Octopamine at night and increases ERG amplitudes drives efferent fibers that run from the brain to the lateral eye of the horseshoe crab. At ambient temperatures, in vitro investigations have revealed that Octopamine induces response prolongations and temporal rescaling (increased latency) while in vivo investigations revealed that nighttime ERGs not only show response prolongation but also acceleration (decreased latency). Since temperature affects the physiology of visual responses in Limulus, the current experiments regulated chamber temperature during in vitro microelectrode recordings from Limulus lateral eye. The purpose of this study was to characterize in vitro effects of Octopamine on response duration and onset at cold temperatures and also to determine if another neuromodulator, Substance P might be involved with response acceleration at both ambient and cold temperatures. Receptor waveforms were recorded from a Limulus lateral eye while either Octopamine or Substance P was perfused. Complementary infusion experiments where a lateral eye was steeped in either Octopamine or Substance P were included in these investigations in order to characterize the interaction effects of each modulator and temperature. Octopamine induced response prolongations accompanied by temporal rescaling with similar probability in cold temperatures as well as ambient temperatures. Substance P was found to modulate the timing of photoreceptor responses by response acceleration. Of particular interest, is the finding that the accelerative effect of Substance P was augmented in cold temperatures, suggesting temperature dependent modulation of sensory signals in the lateral eye of Limulus .
机译：内源性昼夜节律钟在晚上释放八聚氰胺并增加ERG振幅，从而驱动传出的纤维从大脑延伸到​​the的外侧眼。在环境温度下，体外研究表明章鱼胺可引起反应延长和时间上的变化（潜伏期增加），而体内研究表明，夜间ERGs不仅显示反应延长，而且还显示加速（潜伏期减少）。由于温度会影响mul的视觉反应生理，因此当前的实验在Li侧眼的体外微电极记录过程中调节了腔室温度。这项研究的目的是表征章鱼胺在寒冷温度下对反应持续时间和发作的体外影响，并确定在环境温度和寒冷温度下其他神经调节剂P物质是否可能与反应加速有关。在灌注章鱼胺或P物质时，从Li侧眼记录受体波形。这些研究包括补充输注实验，其中侧眼浸入八聚氰胺或P物质，以表征每种调节剂和温度的相互作用。在寒冷温度和环境温度下，章鱼胺引起的反应延长伴随着时间的重新定标，概率相似。发现物质P通过响应加速来调节感光器响应的时间。特别令人感兴趣的是发现物质P的促进作用在寒冷温度下得到了增强，这表明Li的外侧眼中感官信号的温度依赖性调制。

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  • 作者

    Lim, Corrinne Choon Min.;

  • 作者单位

    Purdue University.;

  • 授予单位 Purdue University.;
  • 学科 Psychology Psychobiology.
  • 学位 Ph.D.
  • 年度 2005
  • 页码 187 p.
  • 总页数 187
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 心理学;
  • 关键词

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