• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Development of a novel antimicrobial dental resin root surface treatment for compromised open flap debridement patients.
【24h】

Development of a novel antimicrobial dental resin root surface treatment for compromised open flap debridement patients.

机译：开发了一种新的抗菌牙科树脂牙根表面治疗方法，用于受损的开放性皮瓣清创术患者。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of the study was to develop a novel antimicrobial dental resin root surface treatment with in situ-generated silver nanoparticles for compromised periodontal surgery patients.;Silver nanoparticles were generated in situ in Peak RTM Universal Bond (Ultradent Products, Inc.) with and without chlorhexidine gluconate using different concentrations of silver benzoate (0.025 to 0.1wt%). Bismuth oxychloride (0 to 2 wt%) was added to control the color of the resin. Controls included PeakRTM Universal Bond with and without chlorhexidine gluconate, and in-house formulated resins. Samples were light-cured and tested for degree of cure (Durometer-D hardness), color and color stability (digital colorimetry), shear bond strength, and abrasion resistance (pencil scratch test). In vitro silver ion release was measured for 4 months (atomic absorption spectroscopy) and in vitro antibacterial activity against Porphyromonas gingivalis and Treponema denticola was measured up to three weeks using the optical density method.;The degree of cure of the silver nanoparticles-loaded PeakRTM Universal Bond with and without chlorhexidine was comparable at all bismuth oxychloride concentrations. Increases in silver benzoate concentration darkened the resins but increases in bismuth oxychloride concentration lightened them. Resins with ≤0.05 wt% silver benzoate had clinically acceptable color and were used for further analysis. Silver ion release was detected up to 2 weeks in the silver nanoparticle-loaded PeakRTM Universal Bond without chlorhexidine groups and up to 4 weeks in the silver nanoparticle-loaded PeakRTM Universal Bond with chlorhexidine groups. Silver nanoparticle-loaded groups without chlorhexidine were less abrasion resistant (3H hardness) than controls and silver nanoparticle-loaded groups with chlorhexidine (4H hardness). Increases in silver benzoate concentration decreased shear bond strength, but the 0.025% silver benzoate/2% bismuth oxychloride group with chlorhexidine had comparable shear bond strength to the PeakRTM Universal Bond control (16+/-6 versus 20+/-6 MPa, respectively). Both the 0.05% silver benzoate/2% bismuth oxychloride with chlorhexidine and 0.025% silver benzoate/2% bismuth oxychloride with chlorhexidine groups had significant inhibitory activity against Porphyromonas gingivalis and Treponema denticola (p<.05). The effect against Treponema denticola was significantly stronger than against Porphyromonas gingivalis (p<.05). The higher the silver benzoate concentration, the longer lasting and more significant the antimicrobial effect (p<.05). The 0.05% silver benzoate/2% bismuth oxychloride group had greater inhibitory activity against Porphyromonas gingivalis (up to 22%), and Treponema denticola (up to 42%) than the 0.025% silver benzoate/2% bismuth oxychloride group (up to 15% and 39% inhibition, respectively). Finally, the color stability of these resins was comparable to that of the in-house formulated resin with chlorhexidine control group over two months in vitro..;Silver nanoparticle-loaded PeakRTM Universal Bond with comparable hardness, abrasion resistance, and esthetic properties as control adhesive resins has been developed. Shear bond strength decreased as silver benzoate increased but may be adequate for root surface applications. in vitro silver ion release was measured up to four months. Significant in vitro antimicrobial activity against Porphyromonas gingivalis and Treponema denticola was measured up to three weeks (p<.05). The development of a novel antimicrobial root surface treatment is promising.
机译：该研究的目的是开发一种新的抗菌牙科树脂牙根表面治疗方法，该方法采用原位生成的银纳米颗粒用于牙周手术患者的受损。银纳米颗粒是在Peak RTM Universal Bond（Ultradent Products，Inc.）中与和使用不同浓度的苯甲酸银（0.025至0.1wt％）的无氯己定葡萄糖酸盐。加入三氯氧化铋（0至2重量％）以控制树脂的颜色。对照包括带有或不带有葡萄糖酸洗必泰的PeakRTM Universal Bond，以及内部配制的树脂。将样品光固化并测试其固化程度（Durometer-D硬度），颜色和颜色稳定性（数字比色法），剪切粘合强度和耐磨性（铅笔划痕测试）。使用光密度法测量了长达三个月的体外银离子释放（原子吸收光谱法），并测量了长达三周的体外对牙龈卟啉单胞菌和密螺旋体的体外抗菌活性;负载银纳米颗粒的PeakRTM的固化程度在所有氯氧化铋浓度下，有和没有洗必泰的通用键都相当。苯甲酸银浓度的增加使树脂变暗，但是三氯氧化铋浓度的增加使它们变浅。苯甲酸银≤0.05wt％的树脂具有临床可接受的颜色，可用于进一步分析。在没有洗必泰基团的负载纳米银的PeakRTM通用键中，检测到长达2周的银离子释放；在带有洗必泰基团的负载纳米银的PeakRTM通用键中，检测到银离子释放达4周。不含洗必泰的载有银纳米颗粒的组的耐磨性（3H硬度）比对照组和含洗必泰的有银纳米颗粒的组（4H硬度）差。苯甲酸银浓度的增加会降低剪切键强度，但是0.025％苯甲酸银/ 2％氯己定基团与洗必泰的剪切键强度与PeakRTM通用键对照相当（分别为16 +/- 6和20 +/- 6 MPa） ）。具有氯己定的0.05％苯甲酸银/ 2％氧化铋铋和具有氯己定的0.025％苯甲酸银/ 2％氧化铋对牙龈卟啉单胞菌和密螺旋体都有显着的抑制活性（p <.05）。抗齿垢密螺旋体的作用明显强于牙龈卟啉单胞菌（p <.05）。苯甲酸银浓度越高，持续时间越长，抗菌效果越显着（p <.05）。 0.05％的苯甲酸银/ 2％的氯氧化铋组对牙龈卟啉单胞菌（高达22％）和密螺旋体（最多42％）具有比0.025％的苯甲酸银/ 2％的氯氧化铋组更高的抑制活性。抑制百分比分别为39％和39％）。最后，这些树脂的颜色稳定性在体外两个月内可与内部配制的含洗必泰对照组的树脂相比。.;负载纳米银的PeakRTM Universal Bond具有可比的硬度，耐磨性和美学特性粘合树脂已被开发。剪切粘合强度随苯甲酸银的增加而降低，但可能足以满足根部表面应用的需要。在长达四个月的时间内测量了体外银离子释放。在长达三周的时间内测量到了对牙龈卟啉单胞菌和密螺旋体的显着体外抗菌活性（p <.05）。新型抗菌根表面处理技术的发展是有希望的。

著录项

  • 作者

    Battle-Siatita, Shelrethia.;

  • 作者单位

    The University of Texas Health Science Center at San Antonio.;

  • 授予单位 The University of Texas Health Science Center at San Antonio.;
  • 学科 Dentistry.;Materials science.
  • 学位 M.S.
  • 年度 2016
  • 页码 65 p.
  • 总页数 65
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号