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首页> 外文学位 >Intramembranous and endochondral bone remodeling upon maxillary protraction.
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Intramembranous and endochondral bone remodeling upon maxillary protraction.

机译：上颌前突时膜内和软骨内骨重塑。

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摘要

Objectives. Maxillary protraction is an alternative to surgical maxillary advancement, but little is known about its molecular and cellular mechanisms. This study was to detect bone strains transmitted from maxillary protraction and examine cell differentiation and proliferation in bone remodeling of craniofacial sutures and the cranial base. Methods. Twenty-two, six-week-old, male NZW rabbits were allocated into strain measurement, protraction and control groups. A computer-programmed 2-Newton tensile force was delivered to rabbit's premaxilla. Bone strain was recorded across the premaxillomaxillary suture (PMS) and the nasofrontal sutures (NFS) in strain measurement group. Rabbits in protraction group were loaded for 20 min/d over 12 days following a comprehensive evaluation by using histologic, histomorphometric, immuno-histologic, vital staining, and polarizing microscopic techniques. Results. Bone strain at the PMS was much greater than that of the NFS. Protracted rabbits demonstrated: (1) significant osteogenesis at the PMS showed by Brdu labeling osteoblasts and calcein marked new bone; (2) regional bone resorption occurred at the NFS as evidenced by multinucleated osteoclasts; (3) increased chondrogenesis including chondrocyte proliferation and hypertrophy indicated by high BrdU labeling indices and morphometric measurements at the sphenooccipital synchondrosis (SOS); (4) remarkable trabecular bone formation at SOS subchondral bones; (5) widened and sagittally oriented collagen bands viewed under polarized light at the SOS. Conclusion. The specific strain patterns transmitted from maxillary protraction enhanced both intramembranous bone growth at the PMS and endochondral bone growth at the SOS. Regional osteoclastogenic change at the NFS was likely due to a forward maxillary rotation. Supported by NIH DE13964.
机译：目标。上颌前移是外科上颌前移的替代方法，但对其分子和细胞机制知之甚少。这项研究是要检测从上颌牵伸传播的骨应变，并检查颅面缝线和颅底的骨重塑中的细胞分化和增殖。方法。将22只，六周大的雄性NZW兔分为应变测量组，延长组和对照组。将计算机编程的2牛顿张力传递给兔子的前颌骨。在应变测量组中记录跨上颌前颌骨缝合线（PMS）和鼻额叶缝合线（NFS）的骨应变。通过组织学，组织形态学，免疫组织学，活体染色和偏光显微镜技术进行全面评估后，延长组的兔子在12天之内每天加载20分钟/天。结果。 PMS的骨骼应变远大于NFS的骨骼应变。旷日持久的兔子表现出：（1）Brdu标记成骨细胞，钙黄绿素标记新骨，显示PMS显着成骨； （2）NFS发生局部骨吸收，多核破骨细胞证明了这一点； （3）软骨形成增加，包括高BrdU标记指数和在蝶枕合软骨（SOS）处进行形态测量表明的软骨细胞增生和肥大； （4）在SOS软骨下骨处有明显的小梁骨形成； （5）在SOS的偏振光下观察到的胶原蛋白带变宽且呈矢状。结论。从上颌牵伸传递的特定应变模式既增强了PMS的膜内骨生长，又增强了SOS的软骨内骨生长。 NFS的局部破骨细胞改变可能是由于上颌前旋转所致。受NIH DE13964支持。

著录项

  • 作者

    Wang, Xin.;

  • 作者单位

    University of Illinois at Chicago.;

  • 授予单位 University of Illinois at Chicago.;
  • 学科 Engineering Biomedical.;Health Sciences Dentistry.
  • 学位 M.S.
  • 年度 2004
  • 页码 81 p.
  • 总页数 81
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 遥感技术;
  • 关键词

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