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首页> 外文学位 >Pro-vitamin A Carotenoids: Aspects of the Biology, Chemical Analysis, and Utilization of Foods for Improving Public Health.
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Pro-vitamin A Carotenoids: Aspects of the Biology, Chemical Analysis, and Utilization of Foods for Improving Public Health.

机译：维生素原A类胡萝卜素：生物学，化学分析和食品利用方面的改进公共卫生。

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摘要

Vitamin A deficiency continues to be a public health problem in many countries. Several carotenoids, such as alpha- and beta-carotene and beta-cryptoxanthin found in plants, are capable of forming vitamin A in humans. Pro-vitamin A carotenoid-rich foods are an important and often sole source of vitamin A in many areas of endemic deficiency. Thus, understanding the biological conditions, which types of foods are the most efficacious in providing vitamin A, and the feasibility of these foods to prevent and reduce vitamin A deficiency in humans is critical. Presented first is a review of the literature on the chemistry and potential health benefits of beta-cryptoxanthin, a carotenoid that has not been well studied for its vitamin A potential. Then an examination of the feasibility and effectiveness of using carotenoid-rich foods to provide vitamin A at the individual level and on a global scale is provided. Subsequently, the development and validation of an improved HPLC method is described as well as extraction techniques to efficiently and accurately measure carotenoids and vitamin A in biologicals. Finally, a randomized clinical trial using carotenoid-rich foods as a vitamin A intervention in lactating, vitamin A-deficient women in Bangladesh is discussed. Collectively this research supports the use of pro-vitamin A-rich foods to improve health and reduce and treat vitamin A deficiencies; it also provides evidence of the potential feasibility of using several foods rich in carotenoids to provide vitamin A on a large scale. The continued research into the metabolism and bioefficacy of beta-cryptoxanthin and other pro-vitamin A carotenoids to provide vitamin A in humans is recommended, and investigation into the translation of this science into public health interventions are warranted.
机译：维生素A缺乏症仍然是许多国家的公共卫生问题。几种类胡萝卜素，例如植物中发现的α-和β-胡萝卜素以及β-隐黄质，能够在人体中形成​​维生素A。维生素A原丰富的类胡萝卜素食品在许多地方性缺乏症地区都是维生素A的重要且通常唯一的来源。因此，了解生物学条件，哪种类型的食物最有效地提供维生素A以及这些食物预防和减少人类维生素A缺乏的可行性至关重要。首先介绍的是有关β-隐黄质的化学和潜在健康益处的文献综述，β-隐黄质是一种类胡萝卜素，尚未对其维生素A的潜力进行充分研究。然后，对使用富含类胡萝卜素的食品在个人和全球范围内提供维生素A的可行性和有效性进行了研究。随后，描述了改进的HPLC方法的开发和验证，以及有效和准确地测量生物制剂中类胡萝卜素和维生素A的提取技术。最后，讨论了使用富含类胡萝卜素的食物作为维生素A干预孟加拉国泌乳，维生素A缺乏的妇女的随机临床试验。这项研究共同支持使用富含维生素A的前体食品来改善健康状况，减少和治疗维生素A缺乏症；它还提供了使用多种富含类胡萝卜素的食物大规模提供维生素A的潜在可行性的证据。建议继续研究β-隐黄质和其他前维生素A类胡萝卜素在人体内提供维生素A的代谢和生物功效，并有必要对此技术转化为公共卫生干预措施进行调查。

著录项

  • 作者

    Turner, Tami.;

  • 作者单位

    University of California, Davis.;

  • 授予单位 University of California, Davis.;
  • 学科 Health Sciences Nutrition.;Chemistry Analytical.;Chemistry Biochemistry.;Health Sciences Public Health.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 175 p.
  • 总页数 175
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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