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首页> 外文学位 >Ontogeny of systemic and enteric immune system development and morphological characteristics in neonatal pigs under conventional and segregated early weaning conditions.
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Ontogeny of systemic and enteric immune system development and morphological characteristics in neonatal pigs under conventional and segregated early weaning conditions.

机译：在常规和分离的早期断奶条件下，新生猪的全身和肠道免疫系统发育的个体发育和形态特征。

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摘要

An experiment was conducted to evaluate immune system development and gut morphology in neonatal pigs: (1) pre-weaning; and (2) post-weaning reared under conventional (Conv) and segregated early weaning (SEW) conditions. Prior to weaning, there are changes in the phenotypic expression of blood lymphocytes in addition to a greater functional capacity of these immune cells as the pig increases in age. During the first few weeks of life the young pig may rely on gammadelta T-cell activity and later, once the pig experiences antigen and gets closer to weaning, it relies on further development of the alphabeta T cell repertoire, in addition to the development of the gammadelta T-cell repertoire and population of cytotoxic T cells. Before weaning, the young pig is experiencing alterations in villi width, crypt depth and the number of intestinal sulfuric goblet cells. These changes occurring prior to weaning in lymphocyte phenotypic expression and functional capabilities as well as mucin production may be to further protect the neonate from antigenic stimuli as passive immunity declines. At weaning, the pigs gut architecture is further altered as seen by villus atrophy and crypt hyperplasia; however, there were no alterations due to pig rearing environment. The pigs' immune cell and goblet cell populations are continuing to develop in the intestine after weaning and seem to be further affected by the pigs rearing environment. There was an earlier expansion of CD8+, CD25+ and gammadeltaTCR+ cells in the intestine of SEW pigs than CONV pigs. There were also changes in the number of acidic and sulfuric goblet cells and CD4+ cells over the post-weaning period due to the pigs rearing environment. These changes observed in goblet cells and immune cells in the intestine of newly weaned pigs may be in response to commensal microflora and specific bacteria species entering the intestinal tract, which may play an important role in orchestrating the balance between the inflammatory response and tolerance in the newly weaned pig creating a homeostatic environment where the young pig has the best chance for growth and survival, and may account for the greater growth performance seen in SEW pigs.
机译：进行了一项评估新生猪免疫系统发育和肠道形态的实验：（1）断奶前； （2）在常规（Conv）下饲养的断奶后和早期断奶（SEW）隔离的条件下。断奶前，随着年龄的增长，这些免疫细胞的功能增强，血液淋巴细胞的表型表达也会发生变化。在生命的最初几周中，幼猪可能依赖于γ-δT细胞的活性，后来，一旦猪体经历了抗原并接近断奶，它就需要进一步发展字母T细胞的组成。 γT细胞库和细胞毒性T细胞群体。断奶前，这头小猪的绒毛宽度，隐窝深度和肠道硫酸杯状细胞的数量都有变化。在断奶淋巴细胞表型表达和功能能力以及粘蛋白产生之前发生的这些变化可能是由于被动免疫力下降而进一步保护新生儿免受抗原刺激。断奶时，如绒毛萎缩和隐窝增生所见，猪的肠道结构进一步改变。但是，由于养猪环境没有任何变化。断奶后，小猪的免疫细胞和杯状细胞群体在肠内不断发展，并且似乎进一步受到猪饲养环境的影响。与CONV猪相比，SEW猪肠道中CD8 +，CD25 +和gammadeltaTCR +细胞的扩增更早。在断奶后，由于猪的饲养环境，酸性和硫酸杯状细胞和CD4 +细胞的数量也发生了变化。在刚断奶的猪的肠道中，杯状细胞和免疫细胞中观察到的这些变化可能是对共生菌群和进入肠道的特定细菌物种的响应，这可能在协调炎症反应和耐受性之间的平衡中起重要作用。新断奶的仔猪创造了一个体内稳态的环境，在这种环境中，仔猪具有最佳的生长和存活机会，并且可能解释了SEW猪具有更高的生长性能。

著录项

  • 作者

    Brown, Dari Carisa.;

  • 作者单位

    University of Arkansas.;

  • 授予单位 University of Arkansas.;
  • 学科 Agriculture Animal Culture and Nutrition.; Agriculture Animal Pathology.; Biology Animal Physiology.
  • 学位 Ph.D.
  • 年度 2004
  • 页码 198 p.
  • 总页数 198
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 饲料;动物医学（兽医学）;生理学;
  • 关键词

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