首页> 外文学位 >Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis.
【24h】

Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis.

机译:激活素信号传导在果蝇变态过程中促进胸腺的能力。

获取原文
获取原文并翻译 | 示例

摘要

In insects, the timing of metamorphosis is modulated by a large titer of the steroid hormone ecdysone produced by the prothoracic gland. However, the molecular mechanisms that control production of the ecdysone titer are not completely understood. Here we show that blocking Activin signaling in Drosophila prothoracic gland causes developmental arrest prior to metamorphosis. This defect is due to the absence of the ecdysone titer, a likely consequence of reduced expression of the ecdysone biosynthetic enzymes. We further demonstrate that Activin signaling may regulate the competence of the prothoracic gland to respond to prothoracicotropic hormone and insulin, two hormonal signals that have been shown to trigger ecdysone synthesis. These findings suggest that Activin signaling is required for insect metamorphosis by providing competence that allows tissue- and stage-specific response to metamorphic stimuli.
机译:在昆虫中,变态的时机由胸腺产生的大量滴度的类固醇激素蜕皮激素来调节。然而,控制蜕皮激素滴度产生的分子机制尚不完全清楚。在这里,我们显示阻止果蝇前胸腺中的激活素信号传导导致变态之前的发育停滞。该缺陷是由于缺乏蜕皮激素效价,这可能是降低了蜕皮激素生物合成酶表达的结果。我们进一步证明,激活素信号传导可能调节原腺对原促性激素和胰岛素的反应能力,这两种激素信号已被证明可引发蜕皮激素的合成。这些发现表明,激活素信号传导是昆虫变态所必需的,其提供的能力使组织和阶段对变态刺激具有特异性反应。

著录项

  • 作者

    Gibbens, Ying Ye.;

  • 作者单位

    University of Minnesota.;

  • 授予单位 University of Minnesota.;
  • 学科 Health Sciences Human Development.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 177 p.
  • 总页数 177
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号