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A spatial analysis of invasive breast cancer clusters in association with environmental risk factors: Illinois 1996 to 2000.

机译:与环境危险因素相关的浸润性乳腺癌群集的空间分析:伊利诺伊州,1996年至2000年。

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摘要

This retrospective study assesses invasive breast cancer counts reported at the Illinois ZIP code scale during the study period of 1996 to 2000. The research objective is to evaluate the spatial and statistical associations between breast cancer risk and sources of potential environmental contamination. A thorough literature review illustrates a profound list of cancer risk factors within the study space. Public health principles are utilized to prepare breast cancer incidence for analysis, accompanied with the development of a case/control ecological model. Exploratory analyses suggest that breast cancer intensity is predominantly a rural problem. A generalized linear mixed model is employed, illustrating statistical associations between environmental risk factors and breast cancer risk. Coal Mines, Oil/Gas Wells, and Large Quantity Hazardous Waste Generators, display high statistical significance (p0.001) in association with increased breast cancer risk. Unique socioeconomic attributes distinguish urban risk from rural risk, as can be seen in a discriminant function analysis. The modeling techniques utilized in this research display classic spatial epidemiological approaches that account for particular types of confounding effects, while also defining zones of disease risk through cluster detection. Results from this analysis are useful for future studies intended to account for epidemiological, clinical, chemical and biological disease-related information.
机译:这项回顾性研究评估了1996年至2000年研究期间在伊利诺伊州邮政编码范围内报告的浸润性乳腺癌计数。研究目的是评估乳腺癌风险与潜在环境污染源之间的空间和统计关联。详尽的文献综述阐明了研究空间内癌症风险因素的详尽清单。利用公共卫生原则来准备分析乳腺癌的发生率,并建立病例/对照生态模型。探索性分析表明,乳腺癌的发病率主要是农村问题。使用广义线性混合模型,该模型说明了环境风险因素与乳腺癌风险之间的统计关联。煤矿,油/气井和大量危险废物产生器显示出较高的统计学显着性(p <0.001),同时增加了患乳腺癌的风险。从判别函数分析中可以看出,独特的社会经济属性将城市风险与农村风险区分开来。这项研究中使用的建模技术显示出经典的空间流行病学方法,这些方法可以解释特定类型的混杂效应,同时还可以通过聚类检测来定义疾病风险区域。该分析的结果对于将来的研究是有用的,这些研究旨在解释与流行病学,临床,化学和生物疾病相关的信息。

著录项

  • 作者

    Weston, William C.;

  • 作者单位

    Southern Illinois University at Carbondale.;

  • 授予单位 Southern Illinois University at Carbondale.;
  • 学科 Geodesy.;Health Sciences Oncology.;Health Sciences Epidemiology.;Health Sciences Public Health.
  • 学位 M.S.
  • 年度 2012
  • 页码 130 p.
  • 总页数 130
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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