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Cyclin D1 alterations in giant cell tumor of bone and central giant cell granuloma of the jaw.

机译：骨巨细胞瘤和颌骨中央巨细胞肉芽肿中细胞周期蛋白D1改变。

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Giant cell tumor (GCT) of long bone and central giant cell granuloma (CGCG) of the jaw show similar microscopic features. These tumors can show high proliferative activity suggesting deregulation of the cell cycle control. Therefore, they were assessed for the presence of cyclin D1 gene amplification and protein overexpression and for the expression of cyclin B1 and the proliferation-associated antigen Ki-67. Low level cyclin D1 gene amplification was detected in 61% of GCT and 31% of CGCG. Almost all cases showed cyclin D1 protein overexpression in the giant cells. Cyclin B1 and Ki-67 staining was restricted to the mononuclear cells with no staining present in the giant cells. Cyclin D1 regulation is abnormal in both GCT and CGCG. This supports the possibility that GCT and CGCG are similar diseases and that the clinical and histological differences noted between these two entities maybe due to differences in the anatomical site of involvement.

机译：长骨巨细胞瘤（GCT）和颌骨中央巨细胞肉芽肿（CGCG）表现出相似的微观特征。这些肿瘤可表现出高增殖活性，暗示细胞周期控制的失控。因此，他们评估了细胞周期蛋白D1基因扩增和蛋白过表达的存在，以及细胞周期蛋白B1和增殖相关抗原Ki-67的表达。在61％的GCT和31％的CGCG中检测到低水平的细胞周期蛋白D1基因扩增。几乎所有病例均显示巨细胞中细胞周期蛋白D1蛋白过度表达。细胞周期蛋白B1和Ki-67染色仅限于单核细胞，巨细胞中不存在染色。 GCT和CGCG中的细胞周期蛋白D1调节均异常。这支持了GCT和CGCG是相似疾病的可能性，并且这两个实体之间注意到的临床和组织学差异可能是由于受累的解剖部位不同。

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Kauzman, Adel.;
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University of Toronto (Canada).;

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授予单位 University of Toronto (Canada).;
学科 Health Sciences Dentistry.; Biology Cell.
学位 M.Sc.
年度 2004
页码 137 p.
总页数 137
原文格式 PDF
正文语种 eng
中图分类口腔科学;细胞生物学;
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入库时间 2022-08-17 11:43:24

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Cyclin D1 alterations in giant cell tumor of bone and central giant cell granuloma of the jaw.

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