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Assessment of optic neuropathy as a result of direct and indirect injury using non-invasive functional and structural analytical tools.

机译:使用非侵入性功能和结构分析工具评估直接和间接损伤导致的视神经病变。

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摘要

Optic neuropathy, as a result of various factors, is a leading cause of blindness in the world. The early diagnosis of optic nerve damage can aid therapeutic intervention, and experimental studies characterizing relevant diagnostic tools in different optic neuropathy models are currently lacking. In order to address this gap in current scientific literature, we aim to validate the following overarching hypothesis in this dissertation.;The progression of optic neuropathy as a result of direct and indirect injury to the optic nerve can be reliably assessed using non-invasive functional and structural analytical tools. .;In order to verify this hypothesis, we have conceived and implemented the following specific aims.;Specific Aim I: To characterize optic nerve structure and function using non-invasive tools in healthy C57/bl6 mice.;Specific Aim II: To evaluate optic nerve status in C57/bl6 mice with experimentally induced Parkinson's disease, as a model of indirect injury to the optic nerve.;Specific Aim III: To evaluate optic nerve status in C57/bl6 mice following blast injury, as a model of direct injury to the optic nerve.
机译:由于多种因素导致的视神经病变是世界上失明的主要原因。视神经损伤的早期诊断可有助于治疗干预,目前尚缺乏表征不同视神经病变模型中相关诊断工具特征的实验研究。为了解决当前科学文献中的这一空白,我们旨在验证以下主要假设:可以使用非侵入性功能可靠地评估由视神经直接和间接损伤导致的视神经病变的进展和结构分析工具。为了证实这一假设,我们构想并实现了以下特定目标。具体目标I:使用无创工具在健康的C57 / bl6小鼠中表征视神经结构和功能。具体目标II:评估实验性帕金森氏病的C57 / bl6小鼠的视神经状态,作为对视神经的间接伤害模型。;具体目标III:评估爆炸损伤后C57 / bl6小鼠的视神经状态,作为直接伤害的模型视神经。

著录项

  • 作者

    Mohan, Kabhilan.;

  • 作者单位

    Iowa State University.;

  • 授予单位 Iowa State University.;
  • 学科 Health Sciences Ophthalmology.;Health Sciences Toxicology.
  • 学位 Ph.D.
  • 年度 2012
  • 页码 105 p.
  • 总页数 105
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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