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Principles and operation methods of high performance, portable ion trap mass spectrometry.

机译：高性能便携式离子阱质谱仪的原理和操作方法。

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摘要

Mass spectrometry (MS) is widely used for chemical analysis in many areas, such as homeland security, medical diagnosis, pollution and environment study, molecule detection and identification from space, oil deposits detection, etc. Recently, lot efforts have been put on the miniature ion trap MS system development. Miniature ion trap MS system has the advantages of small dimension, light weight, low cost and easy to use, which makes it a good candidate for fast, onsite chemical detection. Basically there are two ways to miniaturize the ion trap MS system: (1) Decrease the ion trap dimension to lower the radio frequency (RF) voltage requirement and thereby the RF generation circuit; (2) Operate the ion trap at higher pressure regions, which will lower the requirements for the vacuum pumping system. By modeling the ion trajectory as a harmonic pseudo motion, theoretical models are developed, which provide us the ability to characterize the ion trap MS system performances at different operation conditions. Ion trap MS system performances, such as ion capture ability, ion trapping capacity and ion ejection resolution, of scaled ion traps under different buffer gas pressure are calculated. Results show that ion traps on millimeter scale have reasonable performances at relatively high pressure region (1-200 mtorr). Smaller ion traps (on the level of micrometer) can further lower down the RF voltage requirement, but surface roughness effects and array effects will become dominant failure mechanisms.;To improve the performance and simplify the MS system, a discontinuous atmospheric pressure interface ion trap mass spectrometer (DAPI-MS) is built. By using high conductance, discrete ion introduction methods, high efficient ion transfer and high sensitivity is achieved on the instrument. The ion trapping and desolvation are further enhanced by using dual DAPI operations. Ion-molecule and ion-ion reactions (electron transfer dissociation, ETD) are demonstrated on the setup.;A new method which is suitable to operate ion traps at high pressure is also developed based on the high order ion harmonic motion, image current detection method. Pico to Nano ampere level current detector, which can detect ion image current with the presence of AC and RF signal is designed and fabricated. The detector is then integrated with the DAPI-MS system built in house. Ion high order harmonic motion frequency is detected.
机译：质谱（MS）在国土安全，医学诊断，污染和环境研究，从太空进行分子检测和识别，油沉积物检测等许多领域中广泛用于化学分析。最近，人们在这方面进行了很多努力。微型离子阱质谱系统的开发。微型离子阱质谱系统具有体积小，重量轻，成本低和易于使用的优点，使其成为快速，现场化学检测的理想选择。基本上有两种方法可以使离子阱MS系统小型化：（1）减小离子阱尺寸，以降低射频（RF）电压要求，从而降低RF产生电路； （2）在较高压力区域操作离子阱，这将降低对真空泵系统的要求。通过将离子轨迹建模为谐波伪运动，开发了理论模型，这些模型为我们提供了表征不同操作条件下离子阱MS系统性能的能力。计算了不同缓冲气体压力下成比例的离子阱的离子阱MS系统性能，例如离子捕获能力，离子捕获能力和离子喷射分辨率。结果表明，毫米级的离子阱在较高压力区域（1-200 mtorr）下具有合理的性能。较小的离子阱（在微米级别）可以进一步降低RF电压要求，但表面粗糙度效应和阵列效应将成为主要的失效机理。为了提高性能并简化MS系统，不连续的大气压界面离子阱质谱仪（DAPI-MS）已建立。通过使用高电导率，离散的离子导入方法，可以在仪器上实现高效的离子转移和高灵敏度。通过使用双重DAPI操作，可以进一步增强离子捕获和去溶剂化的能力。在装置上演示了离子分子和离子反应（电子转移解离，ETD）。；还基于高阶离子谐波运动，图像电流检测，开发了一种适用于在高压下操作离子阱的新方法。方法。设计并制造了微微至纳安级电流检测器，该检测器可以在存在交流和射频信号的情况下检测离子图像电流。然后将检测器与内部内置的DAPI-MS系统集成在一起。检测到离子高次谐波运动频率。

著录项

  • 作者

    Xu, Wei.;

  • 作者单位

    Purdue University.;

  • 授予单位 Purdue University.;
  • 学科 Chemistry Analytical.;Engineering Electronics and Electrical.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 167 p.
  • 总页数 167
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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