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Bioinformatics and single nucleotide polymorphisms: In silico mapping of complex disease-related traits in mice.

机译：生物信息学和单核苷酸多态性：小鼠复杂疾病相关性状的计算机绘图。

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Experimental murine genetic models of complex human disease show great potential for understanding human disease pathogenesis. To reduce the time required for analysis of such models from many months down to milliseconds, a computational method for predicting chromosomal regions regulating phenotypic traits and a murine database of single nucleotide polymorphisms were developed. After entry of phenotypic information obtained from inbred mouse strains, the phenotypic and genotypic information is analyzed in silico to predict the chromosomal regions regulating the phenotypic trait. These computational predictions reproduce the results of genetic experiments utilizing intercross progeny which required months to years to perform in the laboratory.

机译：复杂人类疾病的实验鼠遗传模型显示出了解人类疾病发病机理的巨大潜力。为了将这种模型的分析所需的时间从几个月减少到毫秒，开发了一种预测调节表型特征的染色体区域的计算方法和一个单核苷酸多态性的小鼠数据库。输入从自交系小鼠品系获得的表型信息后，对计算机的表型和基因型信息进行分析，以预测调节表型性状的染色体区域。这些计算预测重现了利用杂交后代进行的遗传实验的结果，这种杂交需要在实验室中进行数月至数年的时间。

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作者
Usuka, Jonathan Andrew.;
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作者单位

Stanford University.;

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授予单位 Stanford University.;
学科 Chemistry Pharmaceutical.
学位 Ph.D.
年度 2004
页码 111 p.
总页数 111
原文格式 PDF
正文语种 eng
中图分类药物化学;
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机译：编码基因单核苷酸多态性定位和定量性状位点检测的生理性状在布鲁克查尔，Salvelinus fontinalis
2. High-density single nucleotide polymorphisms linkage and quantitative trait locus mapping of the pearl oyster, Pinctada fucata martensii Dunker [J] . Aquaculture . 2014,第Null期

机译：牡蛎Pinctada fucata martensii Dunker的高密度单核苷酸多态性连锁和数量性状基因座定位
3. Identification of Superior Single Nucleotide Polymorphisms (SNP) Combinations Related to Economic Traits by Genotype Matrix Mapping (GMM) in Hanwoo (Korean Cattle) [J] . Lee Yoonseok, Oh Dong-Yep, Lee Yong-Won, Asian-Australasian Journal of Animal Sciences . 2011,第11期

机译：基因型矩阵作图法（GMM）在韩牛（韩国牛）中鉴定与经济性状相关的优良单核苷酸多态性（SNP）组合。
4. Phenotype Prediction of Pathogenic Nonsynonymous Single Nucleotide Polymorphisms in Insulin with Bioinformatics Tools [C] . Guangjian Liu, Shu Zhang, Xuejiao Fan, International Conference on Information Science and Control Engineering . 2018

机译：用生物信息学工具预测胰岛素中病原性非同义单核苷酸多态性的表型
5. The prediction of single nucleotide polymorphisms and their utilization in mapping traits and determining population structure in production animals. [D] . Gorbach, Danielle Marie. 2011

机译：单核苷酸多态性的预测及其在作图特征和确定生产动物种群结构中的用途。
6. Mapping of complex traits by single-nucleotide polymorphisms. [O] . L P Zhao, C Aragaki, L Hsu, 1998

机译：通过单核苷酸多态性映射复杂性状。
7. Mapping of complex traits by single-nucleotide polymorphisms. [O] . Zhao, L P, Aragaki, C, Hsu, L, 1998

机译：通过单核苷酸多态性映射复杂性状。

Bioinformatics and single nucleotide polymorphisms: In silico mapping of complex disease-related traits in mice.

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