首页> 外文学位 >Developpement physiologique des voies visuelles chez le rat normal et chez celui ayant subi des convulsions hyperthermiques.
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Developpement physiologique des voies visuelles chez le rat normal et chez celui ayant subi des convulsions hyperthermiques.

机译:正常大鼠和经历过高热惊厥的大鼠视觉通路的生理发育。

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摘要

Neurons in superficial layers of the rat superior colliculus and primary visual cortex are sensitive to highly contrasted low spatial frequencies drifting at fast speeds. Between post-natal days 27-30 and adulthood, the optimal temporal frequencies of neurons in the primary visual cortex increase, whereas their contrast thresholds decrease. However, the optimal spatial frequencies, spatial resolution values and spatial bandwidths of these neurons are, soon after eyelid opening, similar to those observed in the adult rat. These neuronal response profiles suggest that the retino-collicular and retino-geniculo-cortical projections are mainly innervated by magnocellular and koniocellular retinal ganglion cells.;Keywords : vision, rat, superior colliculus, primary visual cortex, development, febrile seizures, spatial frequency, temporal frequency, direction, contrast.;Neurons in the primary visual cortex of rats having experienced hyperthermic seizures are, soon after eyelid opening, sensitive to low optimal spatial frequencies and show broad directional and temporal bandwidths, as well as elevated contrast thresholds when compared to neurons of normal rats. At adulthood, low optimal temporal frequencies and broad spatial bandwidths are also observed in rats having experienced hyperthermic seizures. The alteration of response profiles of neurons in the primary visual cortex of rats having experienced hyperthermic seizures suggests an unbalance between excitatory and inhibitory mechanisms in this cortical structure. These results also suggest that a single episode of febrile seizures could be sufficient to impede the development of the spatio-temporal receptive field properties of neurons in the primary visual cortex.
机译:大鼠上丘和初级视皮层表层的神经元对快速漂移的高对比度低空间频率敏感。在出生后27至30天到成年之间,初级视觉皮层中神经元的最佳时间频率会增加,而其对比度阈值会降低。然而,眼睑张开后不久,这些神经元的最佳空间频率,空间分辨率值和空间带宽与成年大鼠相似。这些神经元反应谱表明,视网膜-胶质和视网膜-成纤维-皮层的投射主要受大细胞和单核细胞的视网膜神经节细胞的支配;关键词:视觉,大鼠,上丘,初级视皮层,发育,发热性发作,空间频率,眼睑张开后不久,经历高热性癫痫发作的大鼠初级视皮层中的神经元对低最佳空间频率敏感,并显示宽广的方向和时间带宽,以及与之相比升高的对比度阈值正常大鼠的神经元。在成年期,在经历过高热惊厥的大鼠中还观察到了较低的最佳时间频率和较宽的空间带宽。经历过高热性癫痫发作的大鼠初级视皮层神经元反应谱的改变表明,在这种皮层结构中,兴奋机制和抑制机制之间存在不平衡。这些结果还表明,高热惊厥的单发发作可能足以阻碍初级视觉皮层神经元的时空感受野特性的发展。

著录项

  • 作者

    Prevost, Francois.;

  • 作者单位

    Universite de Montreal (Canada).;

  • 授予单位 Universite de Montreal (Canada).;
  • 学科 Psychology Physiological.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 195 p.
  • 总页数 195
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 肿瘤学;
  • 关键词

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