• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >HIV Medication Adherence: Reasons for Missed Medication and Rethinking the Trajectory.
【24h】

HIV Medication Adherence: Reasons for Missed Medication and Rethinking the Trajectory.

机译：HIV药物依从性：药物遗漏的原因和重新思考的轨迹。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

HIV medication adherence is critical for HIV viral suppression and reducing morbidity and mortality. Adherence rates are below optimal levels and women have poorer adherence compared to men. Fifty percent of people treated with antiretroviral therapy (ART) are resistant to at least one medication. Current interventions are costly and magnitude of improvement is often small. Three studies were conducted to examine the reasons why people are missing their medications and the relationship with documented factors. The first study examined key correlates and reasons for missed medication in people from nine cities in the US using an ordinal regression model. Problems taking pills (PTP), (a factor of five reasons) was significantly associated (p=.003) with use of a protease inhibitor (PI) regimen. A person taking a PI regimen is 1.7 odds of having more PTP versus a non-PI based regimen. Symptom experience (OR: 3.8; 95% CI: 2.7, 5.2) and other health conditions (OR: 0.7; 95% CI: .45, .98) were found to be independently associated with PTP. The second study's purpose was to examine and gain an appreciation of the reasons why HIV infected women taking ART in the US are missing their HIV medications, and how the results can influence a new trajectory of adherence research. Women were 2.2 times more likely to document reasons pertaining to forgetfulness than PTP, (OR= 2.2, 95% CI: 1.63, 2.94, p<0.001). There was a difference between the adherent and non-adherent groups in reasons for missed medications given overall, but no difference between those on a PI-based versus a non-PI-based regimen. The final study examined women using a self-management framework and analyzed reasons for non-adherence according to contextual, process and outcome factors. The reasons, 'wanting to avoid side effects' and 'being away from home' were found to have a significant difference when associated with race and employment. The three studies suggest translating the evidence of a common profile of non-adherence into a proactive individual discussion, engaging the patient-provider relationship to appreciate the reasons for intentional or unintentional non-adherence and offers a self-management framework to organize adherence discussions and intervention development.
机译：坚持使用HIV药物对于抑制HIV病毒并降低发病率和死亡率至关重要。坚持率低于最佳水平，女性的坚持率低于男性。抗逆转录病毒疗法（ART）治疗的人中有50％对至少一种药物有抵抗力。当前的干预措施成本高昂，改善幅度通常很小。进行了三项研究，以检查人们为什么缺少药物以及与记载的因素之间的关系。第一项研究使用序数回归模型检查了美国九个城市人群中药物相关的关键相关性和原因。服用药片（PTP）的问题（有五个原因）与蛋白酶抑制剂（PI）方案的使用显着相关（p = .003）。与非基于PI的方案相比，采用PI方案的人拥有更多PTP的可能性为1.7。症状经验（OR：3.8； 95％CI：2.7、5.2）和其他健康状况（OR：0.7； 95％CI：.45，.98）与PTP独立相关。第二项研究的目的是检查并了解为什么在美国接受抗病毒治疗的HIV感染妇女错过了HIV药物的原因，以及结果如何影响依从性研究的新轨迹。妇女记录与遗忘有关的原因的可能性是PTP的2.2倍（OR = 2.2，95％CI：1.63，2.94，p <0.001）。依从组和不依从组之间在总体上漏服药物的原因有所不同，但基于PI的方案与基于非PI的方案之间没有差异。最终研究使用自我管理框架检查了女性，并根据背景，过程和结果因素分析了不坚持的原因。人们发现，“想要避免副作用”和“出门在外”的原因在与种族和就业相关联时具有显着差异。这三项研究建议将普遍存在的不依从性证据转化为积极的个人讨论，让患者与提供者建立关系，以了解有意或无意不依从的原因，并提供一个自我管理框架来组织依从性讨论和干预发展。

著录项

  • 作者

    Okonsky, Jennifer Geralyn.;

  • 作者单位

    University of California, San Francisco.;

  • 授予单位 University of California, San Francisco.;
  • 学科 Womens Studies.;Health Sciences Nursing.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 144 p.
  • 总页数 144
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号