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首页> 外文学位 >Modulation of the immune system in the mammalian intestine as an alternate explanation for the action of antimicrobial growth promoters .
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Modulation of the immune system in the mammalian intestine as an alternate explanation for the action of antimicrobial growth promoters .

机译：调节免疫系统在哺乳动物肠道作为抗菌生长促进剂的作用的另一种解释。

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摘要

The novel hypothesis that antimicrobial growth promoters (AGP) function by modulating the mammalian immune system was tested. Sampling methods to characterize the mucosa-associated microbiota of the murine intestine by terminal restriction fragment length polymorphism (T-RFLP) analysis indicated that direct plug extraction was superior to wash methods. Using T-RFLP analysis, non-therapeutic administration of chlortetracycline (CTC) and sulfamethazine to beef cattle did not affect the composition of bacterial communities associated with intestinal mucosa and in digesta, with exception of those associated with mucosa of the proximal jejunum. Similarly, oral administration of non-therapeutic concentrations of CTC did not affect the mucosa-associated microbiota of the murine intestine. Oral administration of non-therapeutic concentrations of CTC prevented weight loss, reduced pathologic changes, modulated transcription levels of inflammatory cytokines in C. rodentium-infected mice, and did not consistently affect the colonic microbiota. These findings support the hypothesis that AGP primarily function by modulating the intestinal immune system.
机译：测试了抗菌生长促进剂（AGP）通过调节哺乳动物的免疫系统起作用的新假说。通过末端限制性片段长度多态性（T-RFLP）分析来表征鼠肠粘膜相关微生物群的取样方法表明，直接栓塞提取优于清洗方法。使用T-RFLP分析，对肉牛进行非治疗性的金霉素（CTC）和磺胺二甲嘧啶的治疗不会影响与肠粘膜和消化道相关的细菌群落的组成，除了与近端空肠粘膜相关的细菌。同样，口服非治疗浓度的四氯化碳也不会影响鼠肠粘膜相关菌群。口服给予非治疗浓度的四氯化碳可预防体重减轻，减少病理变化，调节感染啮齿类动物的小鼠中炎性细胞因子的转录水平，并且不会持续影响结肠菌群。这些发现支持了AGP主要通过调节肠道免疫系统起作用的假设。

著录项

  • 作者

    Costa, Estela.;

  • 作者单位

    University of Lethbridge (Canada).;

  • 授予单位 University of Lethbridge (Canada).;
  • 学科 Biology Microbiology.;Health Sciences Immunology.;Biology Veterinary Science.
  • 学位 M.Sc.
  • 年度 2011
  • 页码 160 p.
  • 总页数 160
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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