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首页> 外文学位 >Silicon based co-integrated bioelectrical and biomechanical interfaces: Applications to insect olfactory neural interfaces, miniature neural interfaces, and cardiac excitation characterization.
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Silicon based co-integrated bioelectrical and biomechanical interfaces: Applications to insect olfactory neural interfaces, miniature neural interfaces, and cardiac excitation characterization.

机译：硅基共集成的生物电和生物力学接口：在昆虫嗅觉神经接口，微型神经接口和心脏兴奋性表征中的应用。

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摘要

Biosensors have been extremely important in revolutionizing healthcare and environmental monitoring. In combination with Microelectromechanical Systems (MEMS) devices, biological systems can be probed on similar micro and nano dimensions. This can provide a better understanding of how biological systems function and allow for improved treatment methods for diseases and other maladies. However, there are still key limitations in advancing biosensor technology. One of the limitations is biological integration of sensors with tissue for robust interfaces that minimally damage the tissue and can be used in long-term implantations.;In this dissertation, three projects are presented where strategies have been used and developed to minimize biosensor invasiveness. Ultrasonic horn probes driven at their longitudinal resonances can allow penetration of tough tissue, such as cardiac tissue or the dura layer surrounding the brain. For cardiac tissue, ultrasonic probes can allow study of the onset of arrhythmias in 3D. A model governing the force reduction propertions of ultrasonic horn probes dependent on driving voltage, insertion velocity, and substrate elasticity is presented to guide design and use of ultrasonic horn probes in a variety of tissues. The first three-dimensional recordings of action potential propagation during ischemia are obtained. The results show the change in activation delay, action potential duration, action potential amplitude, and morphology through the tissue thickness with ischemia.;Secondly, based on the ultrasonic horn design, a new miniature neural interface system is introduced. This system can allow study of probe insertion force effects on long-term reactions, stress fields around the inserted probes, and changes in electrode impedance and electrical activity from nearby cells over time.;Thirdly, a new hybrid insect olfactory sensor system for gas sensing is presented, which uses Early Metamorphosis Insertion Technology (EMIT) to achieve probe integration. The presented olfactory sensor is based on a silicon neural electrode and is shown to monitor responses to pheromone components and the host plant of the insect, Manduca sexta. The probe sensor is lightweight enough to be carried on the moths.;In the context of these projects, wireless system designs and implementations are presented that allow portability and parallel recording from the tissue. The first system presented is used for wireless transmission of cardiac action potentials, and the second is designed for multiplexed wireless transmission of neural signals. By making the probe and data collection systems fully wireless, wire-induced stresses on probes integrated with tissue can be reduced and serve to reduce damage to the tissues.
机译：生物传感器在彻底改变医疗保健和环境监测方面非常重要。结合微机电系统（MEMS）设备，可以在相似的微米和纳米尺寸上探测生物系统。这可以更好地了解生物系统的功能，并可以改善疾病和其他疾病的治疗方法。但是，在发展生物传感器技术方面仍然存在关键限制。局限性之一是传感器与组织的生物集成，以实现坚固的界面，从而最大限度地减少对组织的损害，并且可用于长期植入。以其纵向共振驱动的超声波角探测器可以穿透坚硬的组织，例如心脏组织或大脑周围的硬脑膜层。对于心脏组织，超声探头可以研究3D心律失常的发生。提出了一种模型，该模型根据驱动电压，插入速度和基底弹性来控制超声变幅杆探针的力降低规定，以指导各种组织中超声变幅杆探针的设计和使用。获得缺血期间动作电位传播的第一个三维记录。结果表明，激活延迟，动作电位持续时间，动作电位振幅和形态随组织厚度的变化随缺血的变化而变化。其次，在超声喇叭设计的基础上，引入了一种新型的微型神经接口系统。该系统可以研究探针插入力对长期反应的影响，插入探针周围的应力场以及附近细胞随时间的电极阻抗和电活动的变化。第三，用于气体传感的新型混合昆虫嗅觉传感器系统介绍了该技术，该技术使用早期变形插入技术（EMIT）来实现探针集成。提出的嗅觉传感器基于硅神经电极，显示可监测对信息素成分和昆虫寄主Manduca sexta的响应。探头传感器重量轻，可以携带在飞蛾上。在这些项目的背景下，提出了无线系统设计和实现，可实现便携性和组织并行记录。提出的第一个系统用于心脏动作电位的无线传输，第二个系统用于神经信号的多路无线传输。通过使探针和数据收集系统完全无线，可以减少与组织整合在一起的探针上的导线引起的应力，并减少对组织的损害。

著录项

  • 作者

    Shen, Ching-Ping Janet.;

  • 作者单位

    Cornell University.;

  • 授予单位 Cornell University.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 185 p.
  • 总页数 185
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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