• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >High-speed MRI-guided near-infrared tomography system to monitor breast hemodynamics in vivo.
【24h】

High-speed MRI-guided near-infrared tomography system to monitor breast hemodynamics in vivo.

机译：高速MRI引导的近红外断层扫描系统，可监测体内的乳房血液动力学。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diffuse spectroscopic imaging of breast cancer with near-infrared (NIR) light can be integrated into magnetic resonance imaging (MRI), to provide local molecular information about the tissue regions. Dynamics within the tissue from pulsatile blood volume and oxygenation levels can be indicative of pathogenic events such as cellular proliferation and angiogenesis. Additionally the pharmacokinetics and leakage of optical contrast agents within these tissues can be helpful in tumor diagnosis. Measurement of these events require a fast imaging system, and in this work a new data acquisition design was studied, which can greatly improve the imaging speed and realize dynamic contrast imaging with combined NIR-MRI exams.;This study demonstrates the technology and methodology to build a NIR tomography system with spectrally-encoded sources in two wavelength bands which is capable of quantifying the temporal oxyhemoglobin and deoxyhemoglobin contrast in breast tissue at a 20 Hz bandwidth. The system was integrated into a 3T MRI system through a customized breast coil interface for simultaneous optical and MRI acquisition. In this configuration, the MR images provide breast tissue structural information for NIR spectroscopy of adipose and fibro-glandular tissue in breast. System stability and noise were carefully characterized, and different reconstruction methods were compared to optimize image quality. Spectral characterization and dynamic performance of the NIR system were verified through a series of phantom experiments. Normal human subjects were imaged with finger pulse oximeter (PO) plethysmogram synchronized to the NIR-MRI system to provide a frequency-locked data reference. Both the raw data from the NIR system and the recovered absorption variation of the breast at two wavelengths showed the same frequency as the PO output, indicating that this system can recover the temporal absorption changes caused by breast hemodynamics. The system was used to spectrally characterize changes in normal fibroglandular and adipose tissue.
机译：可以将具有近红外（NIR）光的乳腺癌扩散光谱成像与磁共振成像（MRI）集成在一起，以提供有关组织区域的局部分子信息。脉动血容量和氧合水平在组织内的动态可指示病原事件，例如细胞增殖和血管生成。另外，这些组织内光学对比剂的药代动力学和泄漏可能有助于肿瘤诊断。这些事件的测量需要一个快速的成像系统，并且在这项工作中，研究了一种新的数据采集设计，该设计可以通过结合NIR-MRI检查大大提高成像速度并实现动态对比成像。建立一个在两个波长带中具有光谱编码源的NIR层析成像系统，该系统能够在20 Hz带宽下量化乳腺组织中的瞬时氧合血红蛋白和脱氧血红蛋白的对比度。该系统通过定制的乳房线圈接口集成到3T MRI系统中，以同时进行光学和MRI采集。在这种配置中，MR图像为乳房中脂肪和纤维腺组织的近红外光谱提供了乳房组织的结构信息。仔细表征了系统稳定性和噪声，并比较了不同的重建方法以优化图像质量。通过一系列的幻像实验验证了近红外系统的光谱表征和动态性能。正常人受试者使用与NIR-MRI系统同步的手指脉搏血氧仪（PO）体积描记仪成像，以提供锁频数据参考。来自NIR系统的原始数据和在两个波长处恢复的乳房吸收变化均显示出与PO输出相同的频率，这表明该系统可以恢复由于乳房血液动力学引起的时间吸收变化。该系统用于光谱表征正常的腓肠和脂肪组织的变化。

著录项

  • 作者

    Li, Zhiqiu.;

  • 作者单位

    Dartmouth College.;

  • 授予单位 Dartmouth College.;
  • 学科 Engineering Biomedical.;Health Sciences Radiology.
  • 学位 Ph.D.
  • 年度 2011
  • 页码 160 p.
  • 总页数 160
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号