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首页> 外文学位 >The effects of organic and inorganic dietary selenium on selenium status and immune function of horses.
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The effects of organic and inorganic dietary selenium on selenium status and immune function of horses.

机译：有机和无机饮食硒对马的硒状态和免疫功能的影响。

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摘要

Selenium (Se) is a trace element essential for animal and human cell biology. Incorporated into selenoproteins, Se is an integral part of several antioxidant enzymes, including glutathione peroxidase and thioredoxin reductase. In addition to other well recognized roles of Se, such as in thyroid metabolism, an important research focus has been Se and its role in immune function. The selenium status of horses is determined by geographical location and management practices.;In the second study, different methods of Se supplementation were compared in adult, non-pregnant horses. Horses received either no supplementary Se, access to Se-containing trace mineral block, or Se-enriched hay, obtained from fields after application of Se-containing fertilizer. The concentration of Se in fresh forage and hay was increased from concentrations considered inadequate to meet dietary requirements to those considered adequate. Both Se-enriched hay and the Se-containing trace mineral block significantly increased the plasma and red blood cell Se concentrations of adult horses. However, horses fed Se-enriched hay had significantly higher plasma Se concentrations when compared to horses with access to the Se-containing trace mineral block.;The third study investigated the effects of dietary Se on the Se status of broodmares and their foals, as well as, measures of immune function in foals. Se source fed to mares during late pregnancy and early lactation influenced the red blood cell Se concentrations of their foals at one month of age with organic Se leading to higher red blood cell Se when compared to inorganic Se. Mare blood and milk Se as well as foal blood Se at birth were not affected by Se source. Furthermore, the blood Se status of mares during late pregnancy was correlated with their colostrum Se and early lactation milk Se. Selenium source influenced relative gene expression of foal lymphocyte cytokines, namely IL-2, TNFalpha, and IFNgamma; however, no Se source consistently led to alteration in expression.;In conclusion, different methods of Se supplementation, including Se-fortified forage, can be used to improve the Se status of horses in Se-deficient regions. In adult, non-pregnant horses, organic Se is consistently superior to inorganic Se in raising blood Se; however, this effect of dietary Se source could not be demonstrated as clearly in broodmares and their foals. Selenium may contribute to alterations in immune function of horses through changes of relative cytokine gene expression, however, the significance of these observations remains to be clarified.;In the first study, the effects of Se supplementation and source of dietary Se on blood Se status and measures of immune function were investigated in adult, non-pregnant horses. Plasma and red blood cell Se concentrations were highest in horses in the organic Se group when compared to horses in the inorganic Se group or control group. Dietary Se content and source led to alterations in relative lymphocyte expression of IL-5, and relative neutrophil expression of IL-1 and IL-8.
机译：硒（Se）是动物和人类细胞生物学必不可少的微量元素。硒与硒蛋白结合后，是多种抗氧化酶的组成部分，其中包括谷胱甘肽过氧化物酶和硫氧还蛋白还原酶。除硒在甲状腺代谢中的其他公认作用外，硒及其在免疫功能中的作用也是一个重要的研究重点。马的硒状况取决于地理位置和管理方法。在第二项研究中，比较了成年，未怀孕马的不同硒补充方法。马不接受补充硒，使用含硒的微量矿物质块或富含硒的干草，这些干草是在施用含硒肥料后从田里获得的。新鲜草料和干草中的硒含量从认为不足以满足饮食要求的浓度增加到认为足够的浓度。富硒干草和含硒微量矿物质块均显着提高了成年马的血浆和红细胞硒浓度。然而，饲喂富含硒的干草的马与获得含硒的微量矿物质块的马相比，血浆中的硒浓度要高得多。第三项研究调查了饮食中硒对亲鱼及其小马的硒状态的影响，因为以及测量小马驹免疫功能的方法。妊娠后期和早期哺乳期间喂母马的硒源影响了它们驹中一个月的红细胞硒浓度，与无机硒相比，有机硒导致红细胞硒含量更高。母血，母乳中的硒以及驹子中的血硒不受硒来源的影响。此外，母马在妊娠后期的血液中硒状态与其初乳硒和早期哺乳期牛奶硒相关。硒源影响了驹淋巴细胞细胞因子IL-2，TNFα和IFNγ的相对基因表达。总的来说，可以采用不同的补充硒方法，包括用硒强化饲料，以改善缺硒地区马的硒状况。在成年的非怀孕马中，有机硒在增加血液硒方面一直优于无机硒。然而，饮食中硒源的这种作用不能在亲鱼及其小马驹中清楚地证明。硒可能通过改变细胞因子相关基因表达而改变马的免疫功能，但是，这些发现的意义尚待阐明。；在第一项研究中，补充硒和饮食中硒的来源对血液中硒状态的影响和免疫功能的措施进行了调查，成年，非怀孕的马。与无机硒组或对照组的马相比，有机硒组的马血浆和红细胞硒浓度最高。饮食中硒的含量和来源会导致IL-5的相对淋巴细胞表达以及IL-1和IL-8的相对嗜中性粒细胞表达发生变化。

著录项

  • 作者

    Montgomery, Julia Bettina.;

  • 作者单位

    University of Prince Edward Island (Canada).;

  • 授予单位 University of Prince Edward Island (Canada).;
  • 学科 Agriculture Animal Culture and Nutrition.;Biology Veterinary Science.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 220 p.
  • 总页数 220
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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