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首页> 外文学位 >Attenuation based quantification of interstitial lung disease using high resolution computed tomography and correlation with pulmonary function tests.
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Attenuation based quantification of interstitial lung disease using high resolution computed tomography and correlation with pulmonary function tests.

机译：使用高分辨率计算机断层扫描以及与肺功能测试的相关性，基于衰减的间质性肺疾病量化。

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摘要

Interstitial lung disease (ILD) is a chronic and progressive pulmonary disease of the lung parenchyma resulting in fibrotic scar formation of the pulmonary alveoli. The pathologic changes in the lung result in restrictive impairment of lung function. High resolution computed tomography (HRCT) of the chest has become an essential technique in diagnosing and assessing the extent of ILD. Clinical evaluation by HRCT is usually qualitative, leading to inter-observer variability particularly in detecting early disease. We propose a quantitative attenuation-based analysis to standardize the assessment of regional lung disease. We hypothesize that early ILD is associated with greater regional heterogeneity than advanced ILD. To test the hypothesis a method of voxel-wise HRCT image analysis is used to quantify regional lung tissue and air volume within and among lobes.;We analyzed HRCT (0.625mm intervals from apex to base) obtained at prone end-inspiration, supine end-inspiration and supine end-expiration in 29 patients with ILD. Each lobe was reconstructed separately. Regional air and tissue volumes, and fractional tissue volume (FTV=tissue/ [air + tissue] volume) were expressed along standard x,y,z axes. FTV increased with increasing ILD severity especially in the periphery. Lobar FTV correlates inversely with global lung function in all lobes. Early ILD is associated with greater FTV heterogeneity within lobes. With increasing ILD severity, FTV heterogeneity within lobes decreases while FTV heterogeneity among lobes increases.;We conclude that quantitative analysis of FTV can provide clinically relevant markers of regional ILD. ILD severity is associated with decreasing intra-lobar and increasing interlobar FTV heterogeneity, best assessed at prone end-inspiration.
机译：间质性肺疾病（ILD）是一种慢性和进行性肺实质的肺部疾病，导致肺泡形成纤维化瘢痕。肺部的病理变化导致肺功能受限。胸部的高分辨率计算机断层扫描（HRCT）已成为诊断和评估ILD程度的重要技术。 HRCT的临床评估通常是定性的，导致观察者之间存在差异，尤其是在发现早期疾病方面。我们提出了基于定量衰减的分析，以标准化区域性肺病的评估。我们假设早期ILD比晚期ILD与更大的区域异质性相关。为了验证这一假设，使用了基于体素的HRCT图像分析方法来量化肺叶内和肺叶之间的局部肺组织和空气量。我们分析了俯卧末端吸气，仰卧末端获得的HRCT（从顶点到基部的间隔为0.625mm）吸气和仰卧末端呼气治疗29例ILD。每个瓣分别重建。沿标准x，y，z轴表示区域空气和组织的体积，以及分数组织的体积（FTV =组织/ [空气+组织]的体积）。 FTV随着ILD严重程度的增加而增加，尤其是在周围。大叶FTV与所有肺叶的整体肺功能成反比。早期ILD与叶内更大的FTV异质性有关。随着ILD严重程度的增加，肺叶内的FTV异质性降低，而肺叶间的FTV异质性增加。我们得出结论，对FTV的定量分析可以提供区域性ILD的临床相关标志。 ILD的严重程度与叶内减少和叶间FTV异质性增加有关，最好在俯卧末端吸气时进行评估。

著录项

  • 作者

    Watharkar, Snehal S.;

  • 作者单位

    The University of Texas at Arlington.;

  • 授予单位 The University of Texas at Arlington.;
  • 学科 Engineering Biomedical.
  • 学位 M.S.
  • 年度 2010
  • 页码 67 p.
  • 总页数 67
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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