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Optoacoustic detector arrays for medical imaging applications.

机译：用于医学成像应用的光声检测器阵列。

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摘要

Better image resolution would expand the frontiers of ultrasound for both clinical diagnostics and medical research, particularly with spatial resolutions at the subcellular level (≤10μm). The limit on spatial resolution for a particular ultrasound imaging system is imposed by the system electronics together with the physical and electrical characteristics of the array elements. In general, the system electronics is not the technologically limiting factor, and the array element characteristics depend on the method used to generate and detect ultrasound: piezoelectric, capacitive, or optical.; Optoacoustic (OA) detectors have been much-touted for their potential as high resolution, high bandwidth transducers with the possibility of miniaturization, selectable operating frequency, and simple fabrication. For medical applications, the reduced sensitivity of existing OA array detectors with respect to piezoelectric detectors is a considerable deterrent. We have studied stabilized resonant structures for high sensitivity optical detection of ultrasound in medical imaging applications. The theoretical performance of Fabry-Perot (FP) resonant optical elements is well documented, and we establish the parameters required of an ideal FP-based OA detector for sensitivity equivalence to ideal piezoelectric array elements. High-finesse structures are required to achieve the desired sensitivities. Not only are there challenges associated with fabricating FP resonators of high finesse, but the goal of using such a device as an imaging array with an acceptable dynamic range is shown to lead to the requirement of mirror surface imperfections and thickness uniformity constrained to better than that possible with state-of-the-art fabrication methods. We have studied active stabilization of the FP element as a means of circumventing this constraint.; The methods available to effect stabilization include control of (1) laser wavelength, (2) physical path length, and (3) index of refraction. With the promise of sufficient tuning range, high tuning sensitivity, excellent bandwidth, high stability and ease of implementation, index of refraction control is the most attractive approach. Simulations of thermo-optic and electro-optic stabilization for resonant optoacoustic detectors indicate excellent potential for use as array detectors. We have fabricated prototypes of index of refraction stabilized resonant optoacoustic detectors and demonstrate their potential for use as sensitive optoacoustic detectors.
机译：更好的图像分辨率将扩大超声在临床诊断和医学研究方面的领域，特别是在亚细胞水平（≤10μm）的空间分辨率下。特定超声成像系统的空间分辨率限制是由系统电子设备以及阵列元件的物理和电气特性共同决定的。通常，系统电子器件不是技术上的限制因素，并且阵列元件的特性取决于用于产生和检测超声波的方法：压电，电容或光学。光声（OA）检测器作为高分辨率，高带宽传感器的潜力而广受吹捧，它具有小型化，可选的工作频率和简单的制造可能性。对于医疗应用而言，现有的OA阵列检测器相对于压电检测器的降低的灵敏度具有很大的威慑力。我们已经研究了用于医学成像应用中超声的高灵敏度光学检测的稳定谐振结构。 Fabry-Perot（FP）谐振光学元件的理论性能已得到充分证明，并且我们建立了理想的基于FP的OA检测器所需的参数，以实现与理想的压电阵列元件等效的灵敏度。需要高精细的结构才能实现所需的灵敏度。制造高精细的FP谐振器不仅存在挑战，而且使用这种器件作为具有可接受的动态范围的成像阵列的目标也显示出对镜面缺陷和厚度均匀性的要求要比其更好的要求。使用最先进的制造方法可以实现。我们已经研究了FP元件的主动稳定化，以此来规避此约束。可以实现稳定化的方法包括控制（1）激光波长，（2）物理路径长度和（3）折射率。有了足够的调谐范围，高调谐灵敏度，出色的带宽，高稳定性和易于实现的承诺，折射率控制是最有吸引力的方法。谐振光声检测器的热光和电光稳定度仿真显示出用作阵列检测器的巨大潜力。我们已经制造出了折射率稳定共振光声检测器的原型，并展示了其用作灵敏光声检测器的潜力。

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  • 作者

    Spisar, Monica Marie.;

  • 作者单位

    University of Michigan.;

  • 授予单位 University of Michigan.;
  • 学科 Engineering Biomedical.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 113 p.
  • 总页数 113
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
  • 关键词

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