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The changes in bone health and biochemical markers of bone turnover in eumenorrheic females with an increase in weight-bearing training volume.

机译：随着负重训练量的增加，雌性漏尿女性的骨骼健康和骨骼更新的生化标志物的变化。

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摘要

A commonly used device to identify risk for a stress injury to bone, and to monitor bone status in an injured population is the DEXA Scan, which determines BMD. The DEXA scan however, is an inappropriate means to monitor the changes in bone status in an young active population, due to the relatively short convalescence period following a stress injury, the small absolute change in BMD and the precision of the DEXA scan. The use of Qualitative Ultrasound (QUS) and biochemical markers of bone turnover represent alternative methods to assess bone, which may be more sensitive to acute changes and adaptations within the bone itself. The purpose of this study was to assess the changes in measures of QUS and biochemical markers in females, with participation in a running training program. For this study 40 females between the 30–50 years were compared with age and sex matched controls that maintained a constant level of activity throughout the experimental period. During participation in the 20-week training program for the “Charlottesville 10-Miler”, the subjects were assessed for levels of biochemical markers, prior to and prospectively each 5 weeks of the training period. Pre- and post QUS measurements were also performed. Additionally, subjects in the training group were compared according to their pre-training activity level. The results indicated no significant difference in measures of pyridinoline (PYD) in the comparison or training group. However there was a statistically significant correlation between bone alkaline phosphatase (BAP) and participation in the training program (r = 0.236; p 0.01) for the subjects in the training group. These finding suggest an increase in bone formation with no change in bone resorption during the experimental period indicating an improvement in bone health with the participation in the training program. This study was able to identify this change over a relatively short period with the use of biochemical markers, in contrast to the relative stable QUS measures.
机译：DEXA扫描是确定骨应力性受伤风险并监视受伤人群中骨骼状态的常用设备，它可以确定BMD。然而，由于应力损伤后的恢复期相对较短，BMD的绝对变化较小以及DEXA扫描的准确性，DEXA扫描不适用于监测年轻活跃人群的骨骼状态变化。定性超声（QUS）和骨转换的生化标记物的使用代表了评估骨的替代方法，这些方法可能对骨本身的急性变化和适应更为敏感。这项研究的目的是通过参加一项正在运行的培训计划来评估女性的QUS和生化标志物测量值的变化。在这项研究中，将30至50岁之间的40位女性与年龄和性别相匹配的对照进行了比较，这些对照在整个实验期间保持了恒定的活动水平。在参加“ Charlottesville 10-Miler”的20周培训计划期间，在培训期之前和之前每5周评估受试者的生化指标水平。还进行了QUS前后的测量。另外，根据训练前的活动水平比较训练组中的受试者。结果表明，在对照组或训练组中，吡啶啉（PYD）的测量值无显着差异。但是，对于训练组中的受试者，骨碱性磷酸酶（BAP）与参加训练计划之间存在统计学上的显着相关性（r = 0.236; p <0.01）。这些发现表明在实验期间骨形成增加而骨吸收没有变化，这表明参加培训计划可以改善骨骼健康。与相对稳定的QUS措施相比，这项研究能够使用生化标记物在相对较短的时间内识别出这种变化。

著录项

  • 作者

    Kawaguchi, Jeffrey Keith.;

  • 作者单位

    University of Virginia.;

  • 授予单位 University of Virginia.;
  • 学科 Health Sciences Rehabilitation and Therapy.; Health Sciences Recreation.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 189 p.
  • 总页数 189
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 康复医学;预防医学、卫生学;
  • 关键词

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