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首页> 外文学位 >The chemoprevention of lung cancer using nonsteroidal anti-inflammatory drugs (NSAIDs).
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The chemoprevention of lung cancer using nonsteroidal anti-inflammatory drugs (NSAIDs).

机译：使用非甾体抗炎药（NSAID）对肺癌进行化学预防。

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摘要

A number of chronic inflammatory conditions are associated with increased risks of cancer. One of the key features of chronic inflammation is over-expression of the inducible enzyme, cyclooxygenase-2 (COX-2), which is responsible for conversion of arachidonic acid into molecular mediators of inflammation called prostaglandins. A host of recent studies suggest that COX-2 and its byproducts play a role in the development of certain types of cancer. Epidemiologic investigations have consistently shown that regular use of COX-2-inhibiting, non-steroidal anti-inflammatory drugs (NSAIDs) decreases the risk of colon cancer and breast cancer, and selective studies have noted NSAID-associated risk reductions for several other malignancies. However, one major type of cancer that has not been thoroughly investigated for NSAID effects is lung cancer.; To better understand the effect of regular use of NSAIDs on lung cancer development we undertook a case-control study of lung cancer, matching cases and controls for pack-years of cigarette smoking, as well as age and gender. In all, data for 384 cases from the Arthur G. James Cancer Hospital (Ohio State University, Columbus, Ohio) and 384 controls, comprising, participants, in cancer screenings, (breast and prostate) at the same institute were compiled for study. Using the methods of logistic regression, we observed an overall protective effect for NSAIDs against the development of lung cancer (adjusted OR = 0.52, 95% CI = 0.38–0.72). A decrease in risk was observed in both men (adjusted OR = 0.58; 95% CI = 0.38–0.87) and women (adjusted, OR = 0.44, 95% CI = 0.26–0.74). Likewise, significant protective effects of NSAIDs were observed for squamous cell carcinoma (adjusted OR = 0.56, 95% CI = 0.34–0.93) and large cell carcinoma (adjusted OR = 0.32, 95% CI = 0.14–0.72), and a suggestive effect was present for adenocarcinoma (adjusted OR = 0.68; 95% CI = 0.43–1.07). There was also a significant dose response of decreasing relative risk with amount of NSAID use (trend test, p 0.001). These results point to possible chemopreventive effects of NSAIDs against lung cancer in cigarette smokers and suggest a need for further molecular and clinical investigations of the role of COX-2 in lung carcinogenesis.
机译：许多慢性炎症会增加患癌症的风险。慢性炎症的主要特征之一是诱导型酶环氧合酶2（COX-2）的过度表达，该酶负责将花生四烯酸转化为炎症的分子介质，称为前列腺素。最近的大量研究表明，COX-2及其副产物在某些类型的癌症的发生中起作用。流行病学研究一致表明，定期使用抑制COX-2的非甾体类抗炎药（NSAIDs）可以降低结肠癌和乳腺癌的风险，选择性研究已注意到与NSAID相关的其他几种恶性肿瘤的风险降低。然而，尚未对NSAID作用进行彻底研究的一种主要癌症是肺癌。为了更好地了解常规使用非甾体抗炎药对肺癌发展的影响，我们进行了一项肺癌病例对照研究，针对吸烟年限，年龄和性别匹配病例和对照。总共收集了来自同一家研究所的Arthur G. James癌症医院（俄亥俄州立大学，俄亥俄州哥伦布市）的384例病例和384例对照（包括癌症筛查参与者（乳腺癌和前列腺癌））的数据进行研究。使用逻辑回归方法，我们观察到了NSAID对肺癌发展的总体保护作用（校正OR = 0.52，95％CI = 0.38-0.72）。男性（校正后的OR = 0.58； 95％CI = 0.38–0.87）和女性（校正后的OR = 0.44，95％CI = 0.26-0.74）均观察到风险降低。同样，NSAIDs对鳞状细胞癌（调整后的OR = 0.56，95％CI = 0.34–0.93）和大细胞癌（调整后的OR = 0.32，95％CI = 0.14-0.72）也具有显着的保护作用，并且具有提示作用存在于腺癌中（校正OR = 0.68； 95％CI = 0.43–1.07）。随着使用NSAID量的增加，相对危险性也有显着的剂量反应（趋势试验，p <0.001）。这些结果表明，NSAIDs可能对吸烟者的肺癌具有化学预防作用，并表明需要对COX-2在肺癌发生中的作用进行进一步的分子和临床研究。

著录项

  • 作者

    Elliott, Christopher S.;

  • 作者单位

    The Ohio State University.;

  • 授予单位 The Ohio State University.;
  • 学科 Health Sciences Public Health.; Health Sciences Oncology.; Health Sciences Pharmacology.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 127 p.
  • 总页数 127
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;肿瘤学;药理学;
  • 关键词

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