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The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to DNA damage and imbalanced repair.

机译：叶酸缺乏对基础切除修复途径的影响：分析对DNA损伤和失衡修复的酶协调作用。

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The condition of folate deficiency has been implicated in carcinogenesis, with the strongest evidence formulated in colon cancer. The role of folate in DNA repair, DNA synthesis and methylation reactions renders this nutrient an valuable target for studying the onset and progression of cancer. Using molecular techniques to determine gene and protein expression, enzyme activity and methylation status elucidates the mechanism of DNA repair and damage in folic acid deficient animals in response to carcinogen. The findings presented in this study indicate failure to remove and repair damage in the condition of folate deficiency and suggest that the accumulation of DNA base lesions and damage can result in clonogenic selection of initiated cells, driving carcinogenesis.

机译：叶酸缺乏症与致癌作用有关，最有力的证据是结肠癌。叶酸在DNA修复，DNA合成和甲基化反应中的作用使其成为研究癌症发作和进展的重要靶标。使用分子技术确定基因和蛋白质的表达，酶活性和甲基化状态阐明了叶酸缺乏动物对致癌物的DNA修复和破坏的机制。在这项研究中提出的发现表明，在叶酸缺乏的情况下不能消除和修复损伤，并且表明DNA碱基损伤和损伤的积累可以导致起始细胞的克隆形成选择，从而驱动癌变。

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作者
Pilling, Amanda B.;
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作者单位

Wayne State University.;

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授予单位 Wayne State University.;
学科 Health Sciences Nutrition.;Health Sciences Oncology.
学位 Ph.D.
年度 2011
页码 145 p.
总页数 145
原文格式 PDF
正文语种 eng
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1. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity [J] . Salvatore Cortellino, David Turner, Valeria Masciullo, Proceedings of the National Academy of Sciences of the United States of America . 2003,第25期

机译：碱基切除修复酶MED1介导DNA对抗肿瘤药物的损伤反应，并与错配修复系统完整性相关
2. DNA scanning by base excision repair enzymes and implications for pathway coordination [J] . Michael J. Howard, Samuel H. Wilson DNA repair . 2018,第期

机译：通过基础切除修复酶的DNA扫描和途径协调的影响
3. Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway [J] . Chou Wen-Cheng, Hu Ling-Yueh, Hsiung Chia-Ni, Carcinogenesis . 2015,第8期

机译：通过碱基切除修复途径引发ATM-Chk2 DNA损伤反应
4. The Effect of Hydration on the Radiation Induction of DNA Base Lesions Processed by Base Excision Repair Enzymes [C] . Akinari Yokoya, Siobhan Cunniffe, Peter ONeill Workshop on Recognition of DNA Damage as Onset of Successful Repair: Computational and Experimental Approaches, Dec 18-19, 2001, Tokai . 2001

机译：水合对碱基切除修复酶处理的DNA碱基损伤辐射诱导的影响
5. Biological response to 8-oxoguanine base released during DNA base excision repair. [D] . Saenz, David Noe. 2010

机译：DNA碱基切除修复过程中释放的对8-氧鸟嘌呤碱基的生物反应。
6. DNA scanning by base excision repair enzymes and implications for pathway coordination [O] . Michael J. Howard, Samuel H. Wilson -1

机译：碱基切除修复酶进行的DNA扫描及其对途径协调的意义
7. The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrity. [O] . S. Cortellino, D. Turner, V. Masciullo, 2003

机译：碱基切除修复酶MED1介导对抗肿瘤药物的DNA损伤反应，并与错配修复系统的完整性有关。
8. Rational Inhibitors of DNA Base Excision Repair Enzymes: New Tools for Elucidating the Role of BER in Cancer Chemotherapy. Addendum [R] . Krosky, D. J. 2006

机译：DNa碱基切除修复酶的合理抑制剂：阐明BER在癌症化疗中的作用的新工具。附录

The impact of folate deficiency on the base excision repair pathway: Analysis of enzyme coordination in response to DNA damage and imbalanced repair.

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