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首页> 外文学位 >An adventure in crystal engineering: Pyridinecarboxamides and their role in supramolecular chemistry.
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An adventure in crystal engineering: Pyridinecarboxamides and their role in supramolecular chemistry.

机译：晶体工程学的一项冒险：吡啶甲酰胺及其在超分子化学中的作用。

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The designed assembly of a 3-D molecular or ionic solid poses the one of the ultimate challenges in the field of crystal engineering. In order to understand the roles that intermolecular forces play, we choose to start with simple building blocks that are designed to create simple architectures. Like synthetic chemists, crystal engineers are concerned with creating a designed product in good yield. Crystal structures that predictably incorporate a designed intermolecular force (i.e. hydrogen bond) contribute to the supramolecular yield.; Herein, we will report the crystal structures of a variety of metal-organic hybrid solids, as well as purely organic solids. Each of these structures will attempt to make use of the carboxamide moiety to link together neighboring complexes or molecules through hydrogen bonds.; Synthesis of eight new substituted phenylpyridines provides one future direction of this research.{09}By making one of the pieces of the puzzle larger, we hope to create larger networks that would have some degree of porosity. Porous metal-organic hybrid materials pose a wealth of potential in crystal engineering, but the charge on the cationic metal ion must somehow be balanced. Many attempts to accomplish this with conventional anions have resulted in the anion taking up space in an otherwise porous architecture. The use of an anionic ligand with hydrogen-bonding functionalities provides a unique approach to this problem.; Multiple hydrogen-bonding moieties in organic architectures are investigated in order to determine the reliability of the acid/pyridine and the amide/amide hydrogen-bonded synthons. In a high-percentage of cases, these two synthons form in a predictable manner, even in the presence of other moieties. They are not as reliable in the presence of some hydroxyl- and amine moieties.; Finally, the design of the first ternary molecule solids is reported. By understanding the competitive nature of hydrogen bonds, according to the Etter Rule, three different compounds associate with one another in a predictable way. By varying one of these compounds we are able to change the color of the crystalline solid. This achieves one of the primary goals of crystal engineering; namely, function through form.
机译：3-D分子或离子固体的设计组装是晶体工程领域的最终挑战之一。为了了解分子间作用力的作用，我们选择从旨在创建简单架构的简单构建模块开始。像合成化学家一样，晶体工程师也关心如何以高成品率生产设计好的产品。可预测地结合了设计的分子间力（即氢键）的晶体结构有助于超分子产率。在这里，我们将报告各种金属-有机杂化固体以及纯有机固体的晶体结构。这些结构中的每一个将试图利用羧酰胺部分通过氢键将相邻的配合物或分子连接在一起。八种新的取代苯基吡啶的合成为该研究提供了一个未来的方向。{09}通过将难题中的一个扩大，我们希望创建一个具有一定孔隙度的较大网络。多孔金属-有机杂化材料在晶体工程中具有巨大的潜力，但是阳离子金属离子上的电荷必须以某种方式平衡。用常规阴离子完成此目的的许多尝试已导致阴离子在其他多孔结构中占据空间。具有氢键官能团的阴离子配体的使用提供了解决该问题的独特方法。为了确定酸/吡啶和酰胺/酰胺氢键合成子的可靠性，研究了有机结构中的多个氢键部分。在高比例的情况下，即使存在其他部分，这两个合成子也以可预测的方式形成。在某些羟基和胺部分的存在下，它们不那么可靠。最后，报道了第一三元分子固体的设计。根据Etter规则，通过了解氢键的竞争性质，三种不同的化合物以可预测的方式彼此缔合。通过改变这些化合物中的一种，我们能够改变结晶固体的颜色。这实现了晶体工程的主要目标之一。即通过形式发挥作用。

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  • 作者

    Helfrich, Brian Andrew.;

  • 作者单位

    Kansas State University.;

  • 授予单位 Kansas State University.;
  • 学科 Chemistry Organic.; Chemistry Pharmaceutical.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 203 p.
  • 总页数 203
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 有机化学;药物化学;
  • 关键词

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