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Biomarkers of exposure to dietary carbohydrates with an application in gastroenterology.

机译：暴露于饮食碳水化合物的生物标志物在胃肠病学中的应用。

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摘要

Non enzymatic glycated proteins in the blood, the product of the non enzymatic reaction of a reducing sugar with the reactive amino acid of a target protein, are an integrated measure of blood glucose over days to weeks. There are few epidemiological studies in non diabetic subjects on the effect of diet and other behavioral risk factors on markers of protein glycation, and on the association of these markers with disease. We compared the correlation of HbA1c and fructosamine with dietary carbohydrate intake in 59 diabetic and non diabetic subjects. Fructosamine was more strongly correlated with dietary sugar (r = 0.26, p = 0.05) than HbA1c (r = 0.001, p = 0.99). To study the relationship between serum fructosamine and diet in a population sample of non diabetic subjects, we measured diet with a validated semiquantitative food frequency questionnaire in a population sample of 252 subjects (137 men and 115 women) without diabetes and with fasting serum glucose 126mg/100m1. Serum fructosamine was positively associated (p 0.10) with dietary glycemic load, intake of polyunsaturated fats and alcohol; and negatively associated with intake of monounsaturated fats, and with physical activity. The findings of this study support the hypothesis that carbohydrate, and above all high glycemic index carbohydrate, is important in determining the fructosamine level, a measure of glycated serum proteins. In many epidemiological studies dietary sugar has been found to be associated with colorectal cancer, but glycated hemoglobin (HbA1c) has not been found associated with incident colorectal cancer or adenoma, a precursor of colorectal cancer. We compared non diabetic subjects with the first occurrence of adenomatous polyps removed after a complete colonoscopy (153 cases) with subjects with normal colonoscopy (84 controls). In these subjects the risk of colorectal adenoma increased with the level of fructosamine (χ2 for linear trend, p = 0.09), and with increasing levels of serum triglycerides and cholesterol, and decreased with increasing levels of fasting serum insulin. Fasting serum glucose was not associated with adenomatous colorectal polyps. These results show that the risk of colorectal adenoma increases with the level of fructosamine, an indicator of glucose variation in the blood, and of a high glycemic load diet.
机译：血液中的非酶糖基化蛋白质是还原糖与靶蛋白的反应性氨基酸的非酶反应的产物，是几天到几周内血糖的综合指标。在非糖尿病受试者中，关于饮食和其他行为危险因素对蛋白质糖基化标志物的影响以及这些标志物与疾病的关系的流行病学研究很少。我们比较了59名糖尿病和非糖尿病受试者中HbA 1c 和果糖胺与膳食碳水化合物摄入量的相关性。果糖胺与膳食糖的相关性更强（r = 0.26，p = 0.05），而与HbA 1c 无关（r = 0.001，p = 0.99）。为了研究非糖尿病受试者人群中血清果糖胺与饮食之间的关系，我们使用经验证的半定量食物频率问卷对252名无糖尿病且空腹血糖< 126毫克/ 100毫升。血清果糖胺与饮食中的血糖负荷，多不饱和脂肪和酒精的摄入呈正相关（p <0.10）。与单不饱和脂肪的摄入以及身体活动负相关。这项研究的发现支持以下假设：碳水化合物，尤其是高血糖指数的碳水化合物，对于确定果糖胺水平（衡量糖化血清蛋白的水平）很重要。在许多流行病学研究中，人们发现饮食中的糖与大肠癌有关，但尚未发现糖化血红蛋白（HbA 1c ）与大肠癌或大肠癌的前体腺瘤有关。我们将完全结肠镜检查后首次切除腺瘤性息肉的非糖尿病患者（153例）与正常结肠镜检查的患者（84例）进行了比较。在这些受试者中，结直肠腺瘤的风险随着果糖胺水平的升高而增加（线性趋势χ2，p = 0.09），并且随着血清甘油三酸酯和胆固醇水平的升高而增加，而随着空腹血清胰岛素水平的升高而降低。空腹血糖与腺瘤性结肠息肉无关。这些结果表明，结直肠腺瘤的风险随着果糖胺水平的升高而增加，果糖胺水平是血液中葡萄糖变化的指标，并且是高血糖负荷饮食。

著录项

  • 作者

    Misciagna, Giovanni.;

  • 作者单位

    State University of New York at Buffalo.;

  • 授予单位 State University of New York at Buffalo.;
  • 学科 Health Sciences Public Health.; Health Sciences Nutrition.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 133 p.
  • 总页数 133
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;预防医学、卫生学;
  • 关键词

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