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Kinesiographic lesion monitoring (KLM).

机译：人体运动学病变监测（KLM）。

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During High Intensity Focused Ultrasound (HIFU) therapy, it is important to monitor the dose applied to the treatment volume to assure sufficient treatment but not excessive treatment. The successful use of acoustic energy to cause minimally invasive destruction of cancerous growths requires a method of monitoring the level of treatment being applied. By interrupting treatment several times per second and measuring the rebound displacement the progression of lesion formation can be monitored. Kinesiographic Lesion Monitoring (KLM) is a radiation force based method for measuring displacement correlated with HIFU generated lesions in tissue. KLM has many potential clinical applications, including: real-time detection of lesion growth or “maturation” for “critical dose” or treatment endpoint detection, and motion cancellation to negate lesion motion due to respiration or patient movement. In this method, the tissue is exposed to bursts of uniform power HIFU. During the interval between bursts, the lesion rebound is measured with confocal Doppler ultrasound. The displacement increases as the temperature in the lesion rises causing an increase in local attenuation; opposing that the displacement decreases as the tissue stiffens with increasing treatment. The two opposing effects create a curve that increases then decreases with increasing therapeutic dose. By terminating treatment at the maximum rebound displacement, uniform dose is assured. This method has been demonstrated in vitro in bovine liver.
机译：在高强度聚焦超声（HIFU）治疗期间，重要的是监视应用于治疗量的剂量，以确保进行充分的治疗，而不是过多的治疗。成功地利用声能以最小的侵入性破坏癌的生长，需要一种监测所用治疗水平的方法。通过每秒中断几次治疗并测量回弹位移，可以监测病变形成的进程。人体运动学病变监测（KLM）是一种基于辐射力的方法，用于测量与HIFU在组织中产生的病变相关的位移。 KLM具有许多潜在的临床应用，包括：实时检测病灶的生长或“成熟”以进行“关键剂量”或治疗终点检测，以及通过运动消除以消除由于呼吸或患者运动引起的病灶运动。在这种方法中，组织暴露于均匀功率HIFU的脉冲串中。在爆发之间的间隔期间，用共聚焦多普勒超声测量病变反弹。位移随着病变温度的升高而增加，从而导致局部衰减的增加。相反，随着治疗的增加，位移随着组织变硬而减小。两种相反的作用形成一条曲线，该曲线随治疗剂量的增加先增加后减少。通过以最大回弹位移终止治疗，可确保剂量均匀。该方法已在牛肝中体外证明。

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