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首页> 外文学位 >Effect of composition on periprosthetic fluid rheology and friction in total knee arthroplasty.
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Effect of composition on periprosthetic fluid rheology and friction in total knee arthroplasty.

机译：组成对全膝关节置换术中假体周围流变学和摩擦的影响。

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摘要

The present thesis investigates the friction properties of total knee replacement components using lubricating fluids of different composition and rheology. The first stage of the thesis involves characterization of the rheological properties of hyaluronic acid (HA)/bovine calf serum (BCS) solutions. With increased concentration and molecular weight of HA, higher viscosities and more pronounced shear thinning in steady shear flow was observed. In dynamic oscillatory flow, the elastic character of the solutions became more pronounced and the cross-over frequency decreased upon increasing concentration and molecular weight of HA.;The third part of the thesis involves the investigation of the effect of fluid composition on the coefficient of friction in knee replacement components. With increased concentration of HA in solution (0-1mg/mL), the coefficient of friction of HA/BCS solutions decreased. However, with HA/BCS solutions of higher HA concentrations (above 1mg/mL), no significant difference in the coefficient of friction was observed. Similar behavior was observed with HA/Albumin solutions. With HA/D.I. water solutions, the coefficient of friction was almost identical irrespective of the concentration of HA in solution. Significant difference in the rheological properties of HA/D.I. water solutions did not affect the coefficient of friction. The Stribeck analysis revealed that the coefficient of friction with HA/BCS and HA/D.I. water lubrication was not governed by hydrodynamic conditions.;The fourth part of this thesis involved characterization of lubricating fluids before and after friction testing. Absorbance and dynamic light scattering measurements of HA/BCS solutions and of HA/Albumin solutions indicate a rise in turbidity and the presence of larger size particles in these solutions after friction testing. The ninhydrin test confirmed the presence of protein in the precipitates obtained following testing.;The second part of the thesis involves the determination of a method by which the coefficient of friction is estimated using a linear reciprocating wear testing machine with spherical metal indenters articulating on flat UHMWPE samples and deionised (D.I.) water lubrication. A characteristic periodic pattern in the friction behaviour was observed and the coefficient of friction was computed by calculating the average of 30 points about the midpoint between reversals and using the average of three cycles.
机译：本文研究了使用不同组成和流变学的润滑液对全膝关节置换组件的摩擦性能。论文的第一阶段涉及透明质酸（HA）/牛犊血清（BCS）溶液的流变特性表征。随着HA浓度和分子量的增加，在稳定剪切流中观察到更高的粘度和更明显的剪切稀化。在动态振荡流中，随着HA的浓度和分子量的增加，溶液的弹性特征变得更加明显，交叉频率降低。论文的第三部分是研究流体组成对HA系数的影响。膝盖替换组件的摩擦。随着溶液中HA浓度的增加（0-1mg / mL），HA / BCS溶液的摩擦系数降低。但是，对于高HA浓度（高于1mg / mL）的HA / BCS溶液，没有观察到摩擦系数的显着差异。用HA /白蛋白溶液观察到类似的行为。使用HA / D.I。在水溶液中，无论溶液中HA的浓度如何，摩擦系数几乎相同。 HA / D.I的流变性质的显着差异。水溶液不影响摩擦系数。 Stribeck分析显示与HA / BCS和HA / D.I的摩擦系数。水润滑不受流体动力条件的影响。本文的第四部分涉及摩擦试验前后润滑液的表征。 HA / BCS溶液和HA /白蛋白溶液的吸光度和动态光散射测量表明，经过摩擦测试后，这些溶液中的浊度有所增加，并且存在较大尺寸的颗粒。茚三酮测试证实了在测试后获得的沉淀物中蛋白质的存在。论文的第二部分涉及确定一种方法，该方法使用线性往复磨损试验机通过球形金属压头在平面上铰接来估算摩擦系数。超高分子量聚乙烯样品和去离子水润滑。观察到摩擦行为的特征性周期性模式，并且通过计算反转之间的中点附近的30个点的平均值并使用三个循环的平均值来计算摩擦系数。

著录项

  • 作者

    Fam, Hala.;

  • 作者单位

    Queen's University (Canada).;

  • 授予单位 Queen's University (Canada).;
  • 学科 Engineering Biomedical.;Engineering Chemical.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 151 p.
  • 总页数 151
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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