• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >The recruitment of new neurons to the song system during the sensitive period for song learning in the zebra finch.
【24h】

The recruitment of new neurons to the song system during the sensitive period for song learning in the zebra finch.

机译：在敏感时期，在斑马雀科学习歌曲的过程中，将新的神经元募集到歌曲系统中。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Adult neuronal replacement is often linked to learning, but the details of this link remain unclear. In zebra finches, new neurons are recruited to the song nucleus HVC at the highest levels during the sensitive period for song imitation, but once learning is over new neuron recruitment declines throughout life. Song imitation can be blocked by deafening, interfering with song system nucleus LMAN, or by removing the innervation of the syringeal muscles. The sensitive period in which zebra finches imitate song can also be extended beyond the normal 90 day period by isolating juveniles from male tutors. We looked at new neuron numbers in zebra finches that were (A) blocked from imitating song by any of the three manipulations above and (B) isolated to extend the sensitive period. We labeled new neurons in experimental and control birds with BrdU, a cell-birth marker, at multiple time points throughout development and perfused them 30 days after BrdU injection. In the youngest birds, in the midst of the sensitive phase for song learning (post-hatching days 30–65), there were no differences between experimental birds and controls in terms of BrdU-labeled neuron numbers. As the sensitive period came to a close, differences in new neuron recruitment appeared in isolates (90–120 or 120–150) and in birds that received unilateral tracheosyringeal denervation (d61–91). No differences were seen in birds that were blocked from imitating song by deafening, LMAN lesion, or bilateral syringeal denervation (d61–91). Thus, we only measured differences in BrdU-labeled neuron counts in birds that were impeded, but not blocked, from imitating a model. These birds maintained more new neurons in HVC thirty days after labeling when compared to controls, but had the same total number of new neurons in HVC. We inferred that these birds had a higher rate of neuronal turnover. Perhaps in the absence of a ‘correct’ learning context (access to a model and bilateral control of the syrinx), the brain withholds commitment to patterns it has learned by maintaining a higher rate of neuronal turnover. When satisfactory learning does occur, then commitment to a learned skill dampens neuronal replacement.
机译：成人神经元置换通常与学习有关，但这种联系的细节仍不清楚。在斑马雀科中，在模仿歌曲的敏感时期，新神经元以最高水平被募集到歌曲核HVC，但是一旦学习结束，新神经元的募集将在整个生命中下降。可以通过震耳欲聋，干扰歌曲系统核LMAN或通过去除注射器肌肉的神经来阻止歌曲模仿。斑马雀模仿歌曲的敏感时期也可以通过将少年与男性家教隔离开来延长到正常的90天以上。我们查看了斑马雀科中的新神经元数量，它们被（A）通过上述三种操作中的任何一种阻止模仿歌曲，并且（B）被隔离以延长敏感期。我们在整个发育过程中的多个时间点，用细胞出生标记BrdU在实验和对照鸟类中标记了新的神经元，并在注射BrdU后30天对其进行了灌注。在最年轻的鸟类中，处于歌曲学习敏感阶段的中间（孵化后30-65天），实验鸟类与对照组之间在BrdU标记的神经元数量方面没有差异。随着敏感期的结束，分离株（90-120或120-150）和接受单侧气管-肾小球神经支配术的鸟类（d61-91）出现了新的神经元募集差异。在因震耳欲聋，LMAN病变或双侧注射神经支配神经受阻而无法模仿歌曲的鸟类中，未见差异（d61–91）。因此，我们仅测量了被阻止但未被阻止模仿模型的鸟类中BrdU标记的神经元计数的差异。与对照组相比，这些鸟在标记后三十天在HVC中保持更多的新神经元，但是在HVC中具有相同的新神经元总数。我们推断这些鸟的神经元更新率更高。也许在没有“正确的”学习环境（无法使用模型和双边控制syrinx）的情况下，大脑通过保持较高的神经元更新率来保留对所学模式的承诺。当确实出现令人满意的学习时，对学习技能的投入就会抑制神经元的替代。

著录项

  • 作者

    Wilbrecht, Linda Elizabeth.;

  • 作者单位

    The Rockefeller University.;

  • 授予单位 The Rockefeller University.;
  • 学科 Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 141 p.
  • 总页数 141
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号