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首页> 外文学位 >The role of inert filler particles in controlling release rates from electrorheological drug delivery systems.
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The role of inert filler particles in controlling release rates from electrorheological drug delivery systems.

机译：惰性填料颗粒在控制电流变药物输送系统释放速率中的作用。

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摘要

Recently, a new class of drug delivery system, called electrorheological (ER) dosage forms, has been investigated. These systems are capable of delivering drugs to the body at rates that can be adjusted after the dose has been administered.; The primary aim of this research is to design a system in which the rate of drug release is not necessarily zero-order, but instead can be altered while the drug is releasing, to study the mechanism of drug release, to investigate the effects of the filler particle size and volume fraction on drug release in the presence and in the absence of an applied electric field (E-field), to study the effects of temperature on drug release, with and without applied E-fields, and to develop a theoretical model to facilitate analysis of the experimental release data.; To study ER drug delivery systems, a model system consisting of different filler particles suspended in a solution of benzocaine (BZN) in olive oil was used. The volume fraction of the filler particles ranged from ∼0.1–80%, and the filler particle sizes ranged from ∼0.2–90 μm. The drug release patterns from these systems were studied by varying different parameters such as particle size, filler fraction, temperatures and E-field strengths. Two different experimental set-ups were designed to study the drug release from the ER systems. In the first design, acrylic cells were used for the donor and receiver. In the second set-up, modified Franz diffusion cells were used for the release experiments. Fick's Laws of diffusion were modified to forms that are applicable to these two-phase ER systems and were solved to derive equations describing the mass vs. time-release profiles. These equations were then evaluated by two numerical simulation methods—random walk and finite differences.; The experimental data show that the filler particles have significant effect on tortuosity, which increases with increasing filler volume fraction. For symmetrical filler particles, the tortuosity increased as the particle size decreased. Although models in the literature indicate that the correlating factor for tortuosity is the filler volume fraction, it was found in this study that the total surface area is the fundamental correlating factor. Drug release from the ER systems can be controlled (enhanced) by the application of a static external electric field. The E-field strengths used in the current study ranged from 0–18 V/mm.; A promising prototype device has been designed which works at much lower E-fields. This design is convenient in the sense that the E-field does not have to straddle, which brings the applicability of these systems much closer to reality. Further studies are being conducted to optimize and fine-tune these systems for programmable drug delivery. (Abstract shortened by UMI.)
机译：最近，已经研究了一种新型的药物输送系统，称为电流变（ER）剂型。这些系统能够以给药后可以调节的速率将药物输送到体内。这项研究的主要目的是设计一个系统，在该系统中，药物释放速率不一定为零级，而是可以在药物释放时进行更改，以研究药物释放的机理，研究药物释放的作用。填料粒径和体积分数在有无电场（电场）存在和不存在的情况下对药物释放的影响，以研究温度在有无电场的情况下对药物释放的影响，并建立理论模型，以方便分析实验性发布数据。为了研究ER药物递送系统，使用了一个模型系统，该系统由悬浮在苯佐卡因（BZN）橄榄油溶液中的不同填充剂颗粒组成。填料颗粒的体积分数在〜0.1–80％的范围内，填料粒径在〜0.2–90μm的范围内。通过改变不同的参数（例如粒径，填料分数，温度和电场强度）研究了这些系统的药物释放模式。设计了两种不同的实验装置来研究从ER系统释放的药物。在第一个设计中，丙烯酸电池用于供体和受体。在第二个设置中，将改良的Franz扩散池用于释放实验。将菲克扩散定律修改为适用于这些两相ER系统的形式，并求解以得出描述质量与时间释放曲线的方程式。然后，通过两种数值模拟方法评估了这些方程式-随机游动和有限差分。实验数据表明，填料颗粒对曲折度有显着影响，随填料体积分数的增加而增加。对于对称的填料颗粒，曲折度随粒径减小而增加。尽管文献中的模型表明曲折度的相关因素是填料体积分数，但在这项研究中发现总表面积是基本的相关因素。可以通过施加静态外部电场来控制（增强）从ER系统释放的药物。当前研究中使用的电场强度范围为0-18 V / mm。已经设计出一种有希望的原型设备，该设备可在低得多的电场下工作。从不必跨越电场的角度来看，这种设计很方便，这使这些系统的适用性更加接近实际。正在进行进一步的研究，以优化和微调这些系统以进行可编程药物输送。 （摘要由UMI缩短。）

著录项

  • 作者

    Nutalapati, Siva Rama Krishna.;

  • 作者单位

    Long Island University, The Brooklyn Center.;

  • 授予单位 Long Island University, The Brooklyn Center.;
  • 学科 Health Sciences Pharmacy.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 224 p.
  • 总页数 224
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药剂学;
  • 关键词

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