首页> 外文学位 >Retrospective analysis of survival and treatment related mortality following a myeloablative hematopoietic stem cell transplant in childhood acute lymphoblastic leukemia.
【24h】

Retrospective analysis of survival and treatment related mortality following a myeloablative hematopoietic stem cell transplant in childhood acute lymphoblastic leukemia.

机译:儿童急性淋巴细胞白血病清髓性造血干细胞移植后生存和治疗相关死亡率的回顾性分析。

获取原文
获取原文并翻译 | 示例

摘要

This internship practicum report evaluates clinical outcomes of high-risk acute lymphoblastic leukemia in young patients who underwent myeloablative hematopoietic stem cell transplant as an alternate to chemotherapy in hopes of long term cure. Scientific literature reveals that presence of specific progressive disease features during therapy and at diagnosis of acute lymphoblastic leukemia categorizes few patients as high-risk ALL. These patients respond poorly to chemotherapy and require durable potential alternatives for long term survival. The use of myeloablative allogeneic hematopoietic stem cell transplant may be offered as an option for potential long term cure. However following transplant remains considerable likelihood of serious post-transplant complications which may jeopardize chances of survival. Longitudinally drawn statistically significant retrospective studies may uncover valuable information and possibly impact decisions when considering a myeloablative allogeneic transplant once a young patient is considered high-risk ALL.
机译:这份实习报告评估了接受清髓性造血干细胞移植作为化疗的替代品,希望长期治愈的年轻患者的高危急性淋巴细胞白血病的临床结局。科学文献表明,在治疗过程中以及在诊断急性淋巴细胞性白血病时,特定的进行性疾病特征的存在将少数患者归为高危ALL。这些患者对化学疗法的反应较差,需要长期使用的潜在替代品才能长期生存。可以使用清髓同种异体造血干细胞移植作为长期治疗的选择。然而,移植后仍然存在严重的移植后并发症的可能性,这可能会危及生存机会。纵向研究具有统计学意义的回顾性研究可能会发现有价值的信息,并可能在考虑将清髓性异体移植手术纳入年轻患者(高危ALL)后影响决策。

著录项

  • 作者

    Dasgupta, Sreejeta.;

  • 作者单位

    University of North Texas Health Science Center at Fort Worth.;

  • 授予单位 University of North Texas Health Science Center at Fort Worth.;
  • 学科 Health Sciences General.;Health Sciences Oncology.
  • 学位 M.S.
  • 年度 2010
  • 页码 94 p.
  • 总页数 94
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号