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首页> 外文学位 >Cystoscopy and the development of invasive bladder cancer in patients presenting with superficial urinary bladder cancer.
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Cystoscopy and the development of invasive bladder cancer in patients presenting with superficial urinary bladder cancer.

机译：膀胱镜检查和浅表性膀胱癌患者的浸润性膀胱癌的发展。

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摘要

The objective of this study was to determine the impact of different follow-up cystoscopy frequencies on time to development of invasive bladder cancer in a cohort of 3,658 eligible patients 65 and older with an initial diagnosis of superficial bladder cancer between 1994 and 1998. Bladder cancer patients in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database were used as the study population.; It was hypothesized that superficial bladder cancer patients receiving less frequent cystoscopy follow-up would develop invasive bladder cancer sooner after initial diagnosis and treatment than patients seen more frequently for cystoscopy follow-up. Cox Proportional Hazard Regression revealed that patients seen for cystoscopy every 3 or more months were 83–89% less likely to develop invasive cancer than patients seen every 1 to 2 months. A comparison of the 2 groups (1 to 2 months vs. 3≥ months) revealed that the 1 to 2 month group may have had more aggressive disease, and they are seen more frequently as a result.; These findings suggest that there are two groups of superficial bladder cancer patients: those at high risk of developing invasive bladder cancer and those at low risk. Patients who developed invasive bladder cancer sooner after initial diagnosis and treatment were seen more frequently for cystoscopy follow-up. The recommendation is that cystoscopy should be based on disease status at 3 months. Standardized schedules give all patients the same number of cystoscopies regardless of their risk factors. This could lead to unnecessary cystoscopies in low risk patients, and fewer than optimal cystoscopies in high risk patients.
机译：这项研究的目的是确定1994年至1998年间3658例符合条件的65岁及以上，初步诊断为浅表性膀胱癌的队列中，不同随访膀胱镜检查频率对浸润性膀胱癌发展时间的影响。膀胱癌监测，流行病学和最终结果（SEER）-医疗保险数据库中的患者被用作研究人群。据推测，接受膀胱镜检查频率较低的浅表膀胱癌患者，在初次诊断和治疗后比发生膀胱镜检查频率较高的患者会更快地发展为浸润性膀胱癌。 Cox比例危害回归显示，每3个月或更长时间进行一次膀胱镜检查的患者比每1-2个月一次进行浸润癌的患者患浸润性癌症的可能性低83-89％。比较两组（1至2个月与3个月以上），发现1至2个月组可能患有更具侵略性的疾病，因此他们的发病频率更高。这些发现表明，有两组浅表性膀胱癌患者：罹患浸润性膀胱癌的高风险患者和低风险的患者。在最初的诊断和治疗后较早出现浸润性膀胱癌的患者，接受膀胱镜检查的频率更高。建议膀胱镜检查应基于3个月时的疾病状况。标准化的时间表会为所有患者提供相同数量的膀胱镜检查，而不受其危险因素的影响。这可能会在低风险患者中导致不必要的膀胱镜检查，而在高风险患者中会比最佳膀胱镜检查少。

著录项

  • 作者

    Amos, Charles E., Jr.;

  • 作者单位

    The University of Texas Health Sciences Center at Houston School of Public Health.;

  • 授予单位 The University of Texas Health Sciences Center at Houston School of Public Health.;
  • 学科 Health Sciences Health Care Management.; Health Sciences Public Health.; Health Sciences Oncology.
  • 学位 Dr.P.H.
  • 年度 2003
  • 页码 61 p.
  • 总页数 61
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 预防医学、卫生学;预防医学、卫生学;肿瘤学;
  • 关键词

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