• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文学位 >Repeated cocaine administration alters medium spiny neuron excitability in the nucleus accumbens core and shell
【24h】

Repeated cocaine administration alters medium spiny neuron excitability in the nucleus accumbens core and shell

机译：重复给予可卡因可改变伏伏核核心和外壳的中棘神经元兴奋性

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Neuroadaptations in the mesocorticolimbic dopamine system, particularly the nucleus accumbens (NAc), are intricately involved in cocaine addiction. Two main regions of the NAc, called the core and the shell, are differentially involved in various aspects of the addiction process. Since excitability largely determines the function of a neuron, I hypothesized that NAc core and shell medium spiny neurons exhibit differences in excitability with repeated cocaine administration. Thus, parameters of excitability, such as action potential (AP) properties, inward rectification, outward rectification and evoked firing were measured in the core and shell after short term (3--4 days) and long term (2--3 weeks) withdrawal from repeated cocaine pretreatment (five days of once daily injection of 15mg/kg i.p.).;After 3--4 days of withdrawal, all measured indices of excitability were decreased in the NAc core but not in the shell. AP threshold was increased, AP amplitude was decreased, inward and outward rectification was increased, and evoked spikes were decreased in the core.;After 2--3 weeks of withdrawal basal suprathreshold excitability was increased in the NAc core, while it was partially decreased in the shell. In the core, AP threshold was decreased, AP amplitude was increased and evoked spikes were decreased, whereas in the shell only AP amplitude was decreased. Inward and outward rectification was not altered in both core and shell.;Re-exposure to a single injection of cocaine after 2--3 weeks of withdrawal abolished the increased excitability of the core, and caused further reduction of excitability in the shell. In the core, AP threshold, AP amplitude and outward rectification were decreased resulting in no change in evoked spikes. In the shell, AP threshold and AP amplitude was decreased, while outward rectification was increased resulting in decreased evoked firing.;The changes in excitability of the core suggest a possible role in short term cocaine withdrawal effects of anhedonia, anergia and tolerance to cocaine reward, as well as the long term withdrawal effects cue-induced cocaine seeking. The changes in excitability of the shell suggest a possible role in cocaine-induced cocaine seeking and craving.
机译：中皮层皮质多巴胺系统中的神经适应，特别是伏伏核（NAc），与可卡因成瘾错综复杂。 NAc的两个主要区域，称为核和壳，在成瘾过程的各个方面有不同的参与。由于兴奋性在很大程度上决定了神经元的功能，因此我假设NAc核心和壳中的多刺神经元在重复给予可卡因后表现出兴奋性差异。因此，在短期（3--4天）和长期（2--3周）后，对核和壳中的兴奋性参数进行了测量，例如动作电位（AP）特性，向内整流，向外整流和诱发放电从重复的可卡因预处理中退出（每天一次注射15mg / kg ip的五天）；退出3--4天后，所有测得的兴奋性指数在NAc核心中降低，但在壳中没有降低。 AP阈值增加，AP幅度降低，内向和外向整流增加，并且在核心中引起诱发的尖峰减少。;戒断2-3周后，NAc核心的基底上阈兴奋性增加，而部分下降在外壳中。在核心中，AP阈值降低，AP幅度增加，诱发尖峰降低，而在壳中，仅AP幅度降低。内核和外壳的内向和外向整流都没有改变。撤药2--3周后再次暴露于一次可卡因的单次注射消除了内核增强的兴奋性，并导致外壳中兴奋性的进一步降低。在核心部分，AP阈值，AP振幅和向外整流降低，导致诱发尖峰无变化。在外壳中，AP阈值和AP幅度降低，而向外矫正则增加，从而引起诱发的放电。 ，以及长期戒断会导致提示可卡因寻求。壳的兴奋性变化表明在可卡因诱导的可卡因寻找和渴望中可能发挥作用。

著录项

  • 作者

    Basu, Somnath.;

  • 作者单位

    The Herman M. Finch University of Health Sciences - The Chicago Medical School.;

  • 授予单位 The Herman M. Finch University of Health Sciences - The Chicago Medical School.;
  • 学科 Pharmacology.;Neurosciences.
  • 学位 Ph.D.
  • 年度 2003
  • 页码 126 p.
  • 总页数 126
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号