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Cardiac function in diabetic mice.

机译：糖尿病小鼠的心脏功能。

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摘要

Background. C57BL/KsJ-leprdb/lep db (db/db) mice exhibit the essential characteristics of type 2 diabetes, with hyperinsulinemia, insulin resistance, and hyperglycemia. It has previously been shown with ex vivo perfusions that hearts from diabetic db/db mice exhibit a cardiomyopathy, with reduced contractile function and altered metabolism. To evaluate whether there is evidence of cardiac dysfunction in vivo, echocardiographic parameters were assessed in intact diabetic db/db mice at both an early (6 weeks of age) and advanced (12 weeks of age) stage of diabetes. Echocardiography provides a non-invasive method to assess both systolic and diastolic function.; Methods. Echocardiograms were obtained in 6 and 12 week conscious and anaesthetized db/db mice, and compared to their 6 and 12 week conscious and anaesthetized control db/+ non-diabetic lean littermates.; Results. In conscious 12 week db/db mice echocardiograms, fractional shortening and circumferential shortening were significantly decreased (59.5 ± 2.3 versus 42.8 ± 2.1% and 11.8 ± 0.4 versus 8.3 ± 0.5) indicating systolic dysfunction. The anaesthetized 12 week db/db mice had significantly increased peak A velocity (0.35 ± 0.03 versus 0.45 ± 0.03 m/sec), and a decreased E/A ratio (3.56 ± 0.29 versus 2.40 ± 0.20) and deceleration time (0.04 ± 0.002 versus 0.05 ± 0.002 sec), evidence of diastolic dysfunction. These changes were not yet detectable in the 6 week db/db mice.; Summary. The decreased in vivo systolic and diastolic function in the 12 week db/db mice confirm the results of cardiac dysfunction in the ex vivo perfusions. Important new insight into the possible mechanisms responsible for cardiac dysfunction in this experimental model of Type 2 diabetes mellitus are given.
机译：背景。 C57BL / KsJ- lepr db / lep db （ db / db ）小鼠表现出2型的基本特征糖尿病，高胰岛素血症，胰岛素抵抗和高血糖症。先前已经显示，通过离体灌注，来自糖尿病 db / db 小鼠的心脏表现出心肌病，收缩功能降低且代谢改变。为了评估是否有体内心脏功能障碍的证据，在早期（6周龄）和晚期（6周龄）对完整的糖尿病性 db / db 小鼠评估了超声心动图参数12周龄）糖尿病阶段。超声心动图提供了一种无创方法来评估收缩功能和舒张功能。 方法。在6周和12周意识清醒并麻醉的 db / db 小鼠中获取超声心动图，并将其与6周和12周意识清醒并麻醉的对照组 db / +非糖尿病瘦仔猪进行比较。; 结果。在有意识的12周 db / db 超声心动图中，缩短分数和圆周缩短显着降低（59.5±2.3对42.8±2.1％和11.8±0.4对8.3±0.5），表明收缩功能障碍。麻醉的12周 db / db 小鼠的A峰值速度显着提高（0.35±0.03对0.45±0.03 m / sec），E / A比降低（3.56±0.29对2.40±0.20）和减速时间（0.04±0.002与0.05±0.002秒），舒张功能障碍的证据。在6周的 db / db 小鼠中还没有检测到这些变化。 摘要。 12周 db / db 小鼠的体内收缩和舒张功能降低，证实了离体灌注的心脏功能障碍的结果。给出了在这种2型糖尿病实验模型中导致心脏功能障碍的可能机制的重要新见解。

著录项

  • 作者

    Semeniuk, Lisa Marie.;

  • 作者单位

    University of Calgary (Canada).;

  • 授予单位 University of Calgary (Canada).;
  • 学科 Biology Animal Physiology.; Health Sciences Pathology.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 924 p.
  • 总页数 924
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生理学;病理学;
  • 关键词

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