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首页> 外文学位 >Hemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance.
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Hemoglobin oxygenation of a two-layer tissue-simulating phantom from time-resolved reflectance.

机译：根据时间分辨的反射率，两层组织模拟体模的血红蛋白氧合。

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摘要

A dual wavelength time-resolved reflectance system was developed for monitoring hemoglobin saturation noninvasively. The ability of the system to determine the optical properties of tissue-simulating phantoms was examined. To quantify the accuracy of the technique in monitoring hemoglobin saturation, measurements were performed in a homogeneous phantom containing human erythrocytes in a scattering solution. The hemoglobin saturation of this phantom could be controlled and monitored with an alternate technique. After system validation in this simple model, a more realistic, two-layer phantom model was investigated. The top layer was chosen to simulate either skin or fat and the oxygenation of the bottom layer, which corresponded to muscle, was controlled. The thickness of the fat layer was varied from 1.5 to 10 mm to investigate the effects of increasing the top layer thickness. Time-resolved measurements of reflectance, performed through the top layer were analyzed with a simple homogeneous diffusion model to quantify the hemoglobin saturation of the bottom layer. These data were compared with simultaneous measurements of oxygenation made directly in the bottom layer. Errors in estimating hemoglobin saturation with this method ranged from 5–11% depending on top layer thickness. Preliminary in vivo measurements were also undertaken which demonstrated promising results, although no comparative technique was used in these studies.
机译：开发了双波长时间分辨反射系统，用于无创监测血红蛋白饱和度。检查了该系统确定组织模拟体模的光学特性的能力。为了量化该技术监测血红蛋白饱和度的准确性，在散射溶液中的均质人体模型中对含有人体红细胞的模型进行了测量。该体模的血红蛋白饱和度可以用替代技术进行控制和监视。在此简单模型中进行系统验证后，研究了一种更现实的两层幻象模型。选择顶层以模拟皮肤或脂肪，并控制与肌肉相对应的底层的氧合。脂肪层的厚度从1.5到10 mm不等，以研究增加顶层厚度的影响。通过简单的均质扩散模型分析通过顶层进行的时间分辨的反射率测量，以量化底层的血红蛋白饱和度。将这些数据与直接在底层进行的同时测量氧合作用进行了比较。该方法估计血红蛋白饱和度的误差范围为5-11％，具体取决于顶层的厚度。尽管这些研究中未使用任何比较技术，但也进行了初步的“体内”测量，该结果显示了令人鼓舞的结果。

著录项

  • 作者

    Hunter, Robert John.;

  • 作者单位

    McMaster University (Canada).;

  • 授予单位 McMaster University (Canada).;
  • 学科 Physics Optics.; Biophysics Medical.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 122 p.
  • 总页数 122
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 光学;生物物理学;
  • 关键词

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