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首页> 外文学位 >Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.
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Functional neuroanatomy during language processing: Correspondence of cortical stimulation mapping, fMRI, PEPSI, and ERP during a visual object naming task.

机译：语言处理过程中的功能神经解剖：在视觉对象命名任务期间，皮质刺激映射，fMRI，PEPSI和ERP的对应关系。

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摘要

This study examines the correspondence of functional language maps using Cortical Stimulation Mapping (CSM), functional MRI (fMRI), Proton Echo-Planar Spectroscopic Imaging (PEPSI), and source localizations from Event-Related Potentials (ERP) during a visual object naming task in two patients undergoing treatment for intractable epilepsy. The spatial relationship between fMRI/PEPSI peak activations and CSM language sites was quantitatively analyzed, indicating minimal correspondence across these techniques. Qualitatively, areas of activation that were common across imaging techniques corresponded well with sites of naming disruption in the anterior superior temporal gyrus and posterior middle temporal gyrus. One control subject participated in fMRI, PEPSI, and ERP sessions and is also examined. For all subjects, fMRI/PEPSI activations and ERP sources for N100 and N400 components were consistent with neuroanatomical areas described for visual object naming in the fMRI and PET literature. Areas most consistently activated across fMRI/PEPSI/ERP techniques were the middle temporal gyrus posteriorly and the superior frontal gyrus and insula anteriorly. ERP scalp distributions for the N100 component across subjects were consistently prominent over anterior sites, while prominent amplitudes for the N400 component varied across subjects in posterior, centro-temporal, and anterior sites. Sources for the N100 component were also consistent across subjects in posterior areas, likely reflecting visual processing, while sources for the N400 component varied across subjects in frontal, temporal, and parietal areas, possibly reflecting not only semantic, but phonological processing as well. Concurrent anterior and posterior fMRI activations appear to be functionally distinguishable based on the ERP source data, again with posterior activations reflecting lower-level visual processing and anterior activations reflecting semantic or phonological processing. Implications for the functional role of specific anatomical structures (e.g. middle temporal gyrus) based on these correspondences are discussed. Theoretical issues pertaining to the physiological mechanisms of CSM disruption, fMRI-BOLD activations, lactate metabolism, and ERP source localizations are also examined to account for matches and mismatches across techniques.
机译：这项研究检查了视觉对象命名任务中使用皮层刺激映射（CSM），功能性MRI（fMRI），质子回波平面光谱成像（PEPSI）以及事件相关电位（ERP）的源定位的功能性语言图的对应性。在接受顽固性癫痫治疗的两名患者中。 fMRI / PEPSI峰激活和CSM语言位点之间的空间关系进行了定量分析，表明这些技术之间的对应关系最小。定性地，在成像技术中常见的激活区域与前颞上回和后颞上回的命名中断位置很好地对应。一名对照受试者参加了功能磁共振成像，PEPSI和ERP会议，并进行了检查。对于所有受试者，fMRI / PEPSI激活和N100和N400组件的ERP来源与fMRI和PET文献中为视觉对象命名所描述的神经解剖区域一致。通过fMRI / PEPSI / ERP技术最一致地激活的区域是后颞中回和前额上回和上岛。 N100成分在受试者中的ERP头皮分布在前部部位始终突出，而N400成分的显着振幅在受试者的后部，中央颞部和前部部位均不同。 N100成分的来源在后方区域中的对象之间也是一致的，可能反映了视觉处理，而N400成分的来源在额叶，颞部和顶叶区域中的对象之间有所不同，可能不仅反映了语义，而且还反映了语音处理。基于ERP源数据，并发的前后fMRI激活在功能上似乎是可区分的，同样，后向激活反映了较低级别的视觉处理，而前向激活反映了语义或语音处理。讨论了基于这些对应关系的特定解剖结构（例如中颞回）的功能作用。还研究了与CSM破坏，fMRI-BOLD活化，乳酸代谢和ERP来源定位的生理机制有关的理论问题，以说明各种技术之间的匹配和不匹配。

著录项

  • 作者

    Serafini, Sandra.;

  • 作者单位

    University of Washington.;

  • 授予单位 University of Washington.;
  • 学科 Biology Neuroscience.; Psychology Psychobiology.; Psychology Cognitive.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 345 p.
  • 总页数 345
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;心理学;心理学;
  • 关键词

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