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首页> 外文学位 >Fiber based scaffolds in connective tissue engineering: Using the architecture of woven scaffolds to influence and control the formation of organized tissues.
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Fiber based scaffolds in connective tissue engineering: Using the architecture of woven scaffolds to influence and control the formation of organized tissues.

机译：结缔组织工程中的基于纤维的支架：使用编织支架的体系结构来影响和控制有组织的组织的形成。

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摘要

The skeleton generates locomotion and provides mechanical support for the human body. It is essential in every aspect of normal living, which is most apparent when it is damaged or rendered useless by disease. The repair of the skeletal system by orthopedists is rather common, occurring millions of times each year. During the 1990s it was estimated that nearly a million cases per year were bone graft cases, which makes them one of the most common forms of transplantation in the United States today.; Orthopedic reconstruction restores function, extending and increasing quality of life. Though progress has been made toward reaching this ideal, bone grafting is still fraught with shortcomings. Its weaknesses become most apparent when large skeletal defects like those seen in osteosarcomal resection are treated. Commonly these reconstructions are performed using allografts combined with steel rods and other devices. Synthetic materials may also be used, but full skeletal incorporation never occurs and they remain inanimate. Because they are non-living, these materials accumulate fatigue and eventually fail.; Cell-based tissue-engineered replacements are a strong candidate to address these challenges. This treatment system would be composed of a synthetic material, like resorbable polymer fibers, combined with cells that are loaded onto the fibers. After implantation the system would foster development of a living and thus self-repairing replacement tissue.; This study focuses on synthetic scaffolds and how they interact with the cells loaded onto them. Established principles of contact guidance were applied to influence orientation and growth of cells on these scaffolds. Guidance of cells and their extracellular matrix (ECM) products is shown on the level of single fibers. More important, however, is the direction of cells and ECM when fibers were organized into regular 3-D structures. Cellular organization and direction far exceeded what has been seen on flat surfaces, or single fibers. The goal of this work was to use scaffold architectures to organize cells and ECM in a 3-D manner as is seen in normal tissues. The results of this study indicate the success of this concept and represent a large step toward the development of this technology.
机译：骨骼产生运动并为人体提供机械支撑。它在正常生活的各个方面都是必不可少的，这在疾病造成的损害或无用的情况下尤为明显。骨科医生修复骨骼系统非常普遍，每年发生数百万次。据估计，在1990年代，每年有近一百万例是骨移植病例，这使其成为当今美国最常见的移植形式之一。骨科重建可以恢复功能，延长并提高生活质量。尽管在达到这个理想方面已经取得了进展，但是植骨仍然充满缺陷。当治疗大型骨骼缺损（如在骨肉瘤切除术中看到的那些缺损）时，其缺点最明显。通常，这些重建是使用同种异体移植物与钢棒和其他装置结合进行的。也可以使用合成材料，但是完全不会合并骨骼，并且它们保持无生命。因为它们没有生命，所以这些材料会累积疲劳并最终失效。基于细胞的组织工程替代品是应对这些挑战的强大候选者。该处理系统将由合成材料（如可吸收的聚合物纤维）与加载到纤维上的细胞组成。植入后，该系统将促进生物的发展，从而自我修复替代组织。这项研究的重点是合成支架以及它们如何与加载到其上的细胞相互作用。已建立的接触指导原则适用于影响这些支架上细胞的方向和生长。在单纤维水平上显示了细胞及其细胞外基质（ECM）产品的指导。然而，更重要的是，当纤维组织成规则的3D结构时，细胞和ECM的方向。蜂窝状组织和方向远远超出了在平坦表面或单纤维上所见的范围。这项工作的目标是使用支架架构以3-D方式组织细胞和ECM，就像在正常组织中看到的那样。这项研究的结果表明了该概念的成功，代表了该技术发展的一大步。

著录项

  • 作者

    Seegert, Charles Alan.;

  • 作者单位

    University of Florida.;

  • 授予单位 University of Florida.;
  • 学科 Engineering Biomedical.; Health Sciences Medicine and Surgery.; Biology Cell.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 152 p.
  • 总页数 152
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;细胞生物学;
  • 关键词

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