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首页> 外文学位 >The impact of the locus coeruleus efferent pathway on thalamic and cortical sensory neuron response properties in the awake rat.
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The impact of the locus coeruleus efferent pathway on thalamic and cortical sensory neuron response properties in the awake rat.

机译：在醒着的大鼠中，蓝斑蓝斑传出途径对丘脑和皮层感觉神经元反应特性的影响。

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摘要

The nucleus locus coeruleus (LC) and its norepinephrine (NE) containing efferent system have been implicated in modulating arousal states and attentional processes.;The goal of this work was to characterize the impact of tonic and phasic LC system output on simultaneously recorded target neurons of the somatosensory thalamus and cortex in the awake behaving rat. The general hypothesis tested in this dissertation is that electrical or chemical manipulations of LC neuron output over the physiological range of tonic discharge frequencies, alters sensory-evoked response properties of target thalamic and cortical neurons recorded simultaneously in the awake freely moving rat.;The first portion of this research was to develop a set of techniques to record the effects of pharmacological or electrical manipulations of the LC on sensory evoked responses of many simultaneously recorded single neurons along the trigeminal somatosensory system of the awake freely moving rat.;The second portion of this research characterized the effects of tonic LC stimulation on the magnitude and latency of whisker pad stimulus-evoked responses. Target cells at the thalamic and cortical levels of the rat trigeminal somatosensory pathway primarily demonstrated either an augmentation or a suppression of the stimulus-evoked discharge over the range of LC stimulus frequencies tested.;The third portion of this research characterized the effects of systemic and local administration of the alpha-2 adrenergic receptor agonist clonidine on whisker pad stimulus-evoked response firing rates and latencies. These treatments resulted in the preferential augmentation of stimulus-evoked discharge for thalamic and cortical neurons.;The fourth portion of this research characterized the effects of phasic LC electrical stimulation on whisker pad stimulus-evoked response firing rates and latencies. Target somatosensory cells of the thalamus and cortex demonstrated augmentation or a suppression of the stimulus-evoked discharge in equal proportions following phasic LC stimulation.;The results of these studies suggest that LC output mediates changes in sensory information processing at the cellular level and that these changes are likely to enhance sensory signal detection and discrimination in the behaving animal. Moreover, the work provides a perspective on how a broadly projecting brainstem modulatory system can coordinately influence signal transmission at multiple stages of a complex, ascending sensory network. (Abstract shortened by UMI.)
机译：大脑核蓝斑（LC）及其去甲肾上腺素（NE）的传出系统与调节觉醒状态和注意过程有关。这项工作的目的是表征补品和分相LC系统输出对同时记录的目标神经元的影响清醒行为大鼠的体感丘脑和皮层的变化。本论文检验的一般假设是，在紧张的放电频率的生理范围内，LC神经元输出的电或化学操纵改变了同时醒着的自由运动大鼠中记录的目标丘脑和皮层神经元的感觉诱发反应特性。这项研究的一部分是开发一套技术来记录LC的药理学或电学操纵对沿清醒自由移动的大鼠的三叉神经体感系统同时记录的许多单个神经元的感觉诱发反应的影响。这项研究表征了强直性LC刺激对晶须垫刺激诱发反应的幅度和潜伏期的影响。在大鼠三叉神经体感测途径的丘脑和皮质水平的靶细胞主要表现出在所测试的LC刺激频率范围内刺激诱发的放电的增强或抑制。 α-2肾上腺素能受体激动剂可乐定在晶须垫刺激诱发的反应激发率和潜伏期的局部给药。这些治疗导致丘脑和皮层神经元的刺激诱发放电优先增加。本研究的第四部分描述了相位LC电刺激对晶须垫刺激诱发的反应激发速率和潜伏期的影响。丘脑和皮层的目标体感细胞在阶段性LC刺激后表现出相等比例的刺激诱发放电增强或抑制。这些研究的结果表明，LC输出介导了细胞水平上的感官信息处理变化，并且这些变化可能会增强行为动物的感觉信号检测和辨别力。此外，这项工作为广泛投射的脑干调制系统如何在复杂的上升感觉网络的多个阶段协调影响信号传输提供了一种视角。 （摘要由UMI缩短。）

著录项

  • 作者

    Devilbiss, David Michael.;

  • 作者单位

    Drexel University College of Medicine.;

  • 授予单位 Drexel University College of Medicine.;
  • 学科 Biology Neuroscience.
  • 学位 Ph.D.
  • 年度 2002
  • 页码 241 p.
  • 总页数 241
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 神经科学;
  • 关键词

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