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The neural systems of working memory: The Sternberg working memory task in a pediatric traumatic brain injury sample.

机译:工作记忆的神经系统:儿科创伤性脑损伤样本中的Sternberg工作记忆任务。

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摘要

Working memory tasks are associated with the activation of widely distributed neural networks. The Sternberg working memory task has been used to explore the neural correlates associated with changes in memory load and the resolution of interference. Preliminary research suggests that the integrity of the anterior cingulate is correlated with resolving load adjustments but not in resolving interference demands; the opposite pattern of associations have been observed with the right middle frontal gyrus.;Participants in the present study were 28 children who had sustained moderate to severe traumatic brain injuries (TBI) and 28 children who had sustained orthopedic injuries (OI). Participants were aged between 7 and 17 years at the time of injury (mean age = 13.2, s.d.=2.3). The groups were matched on age, gender, socioeconomic level, and pre-injury measures of behavioral and emotional functioning. Participants completed the Sternberg working memory task and structural MRI scans three months post injury. Automated brain parcellation software (Freesurfer) was used to calculate volumetric data for regions of interest. Regions of interest included the anterior cingulate and right middle frontal gyrus; additionally, the volume of the corpus callosum was used as an index of overall brain integrity.;There were no significant differences between the groups on percent errors on the Sternberg task. Participants in the TBI group had significantly longer reaction times overall than the OI group. Interference in the Sternberg task has the potential to either help or hinder performance. Participants in the OI group displayed the anticipated effects of interference on reaction time whereas the TBI group as a whole did not display this pattern (priming effect not observed). The TBI group had significantly lower volumes in the regions of interest than the OI group. Hypothesized correlations between the regions of interest and changes in load / interference demands were partially supported. Exploratory analyses identified positive correlations between the volume of the right middle frontal gyrus and reaction time measures that warrant further exploration.;Keywords: traumatic brain injury, Sternberg, working memory, priming, interference, executive functioning.
机译:工作记忆任务与广泛分布的神经网络的激活相关。 Sternberg工作记忆任务已用于探索与记忆负荷变化和干扰解决方案相关的神经相关性。初步研究表明,前扣带的完整性与解决负荷调整有关,但与解决干扰需求无关。右侧中额回的关联方式相反。本研究的参与者为28例中度至重度颅脑外伤(TBI)患儿和28例骨伤(OI)患儿。受伤时参与者的年龄为7至17岁(平均年龄= 13.2,标准误= 2.3)。根据年龄,性别,社会经济水平以及行为和情感功能的伤害前评估对两组进行匹配。参与者在受伤三个月后完成了Sternberg的工作记忆任务和结构MRI扫描。使用自动化的脑细胞分裂软件(Freesurfer)计算感兴趣区域的体积数据。感兴趣的区域包括前扣带回和右中额回。此外,call体的体积被用作整体大脑完整性的指标。组之间在Sternberg任务上的百分比误差没有显着差异。与OI组相比,TBI组的总体反应时间明显更长。对Sternberg任务的干预可能会帮助或阻碍绩效。 OI组的参与者表现出预期的干扰对反应时间的影响,而TBI组的整体没有表现出这种模式(未观察到启动效应)。与OI组相比,TBI组在感兴趣区域的交易量明显更低。部分支持了感兴趣区域与负载/干扰需求变化之间的假想相关性。探索性分析确定了右中额回的体积与反应时间的度量之间的正相关性,值得进一步探索。关键词:颅脑外伤,Sternberg,工作记忆,启动,干扰,执行功能。

著录项

  • 作者

    Pertab, Jon.;

  • 作者单位

    Brigham Young University.;

  • 授予单位 Brigham Young University.;
  • 学科 Biology Neuroscience.;Psychology Psychobiology.;Psychology Clinical.;Psychology Cognitive.
  • 学位 Ph.D.
  • 年度 2010
  • 页码 90 p.
  • 总页数 90
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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