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Secretion and injection of Yops by Yersinia enterocolitica type III systems during infection.

机译：在感染过程中，III型小肠结肠炎耶尔森氏菌会分泌和注射Yops。

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摘要

Many Gram-negative bacteria utilize a dedicated molecular machine to inject virulence factors into the cytosol of host cells during infection. One such bacteria, Yersinia enterocolitica, utilize the type III secretion system to establish lymphadenitis and pertinonitis and yield typical symptoms of abdominal infections that require antibiotic treatment. Yersinia are thought to gain access to the underlying lymphatic tissues where they encounter host macrophages. At the end of this journey most bacteria are presumably killed by macrophages, an obstacle that a pathogen will need to overcome in order to elicit a successful infection. Clearly Yersiniae achieve this goal, given the fact that these microbes multiply within and colonize lymphoid tissues. Upon macrophage contact, Yersiniae activate the type III secretion machinery to inject a set of toxins into the eukaryotic cell. These toxins, named Yersinia outer proteins (Yops), interfere with host cellular processes such as actin polymerization and signal transduction cascades, thereby preventing phagocytosis and killing the macrophage. Work presented herein revealed several events of type III secretion systems during the infection of host cells that allow the delivery of Yop proteins to the extracellular milieu as well as into the host cells. Work also allowed the identification of several potential host signals that may trigger the specific protein export events by derepressing several regulators of the Yersinia type III system. Additionally, mutants of regulatory factors were analyzed to define distinct regulatory pathways of type III secretion during infection of host cells.
机译：许多革兰氏阴性细菌在感染过程中利用专用分子机器将毒力因子注入宿主细胞的细胞质中。其中的一种细菌， Enterocolitica ，利用III型分泌系统来建立淋巴结炎和Pertinonitis，并产生需要抗生素治疗的典型腹部感染症状。据认为，耶尔森氏菌可以进入它们遇到宿主巨噬细胞的下层淋巴组织。在此过程的最后，大多数细菌可能被巨噬细胞杀死，这是病原体引发成功感染所必须克服的障碍。考虑到这些微生物在淋巴组织内繁殖并定殖，显然 Yersiniae 可以达到这一目标。巨噬细胞接触后，耶尔森氏菌激活III型分泌机制，以将一组毒素注入真核细胞。这些毒素被称为耶尔森氏菌外部蛋白（Yops），会干扰宿主细胞的过程，如肌动蛋白的聚合和信号转导的级联反应，从而阻止吞噬作用并杀死巨噬细胞。本文介绍的工作揭示了宿主细胞感染期间III型分泌系统的几种事件，这些事件使Yop蛋白既可以传递到细胞外环境中，也可以传递到宿主细胞中。这项工作还允许鉴定几种潜在的宿主信号，这些信号可能是通过抑制III型耶尔森氏菌系统的调节因子来触发特定的蛋白质输出事件。另外，分析了调节因子的突变体以定义宿主细胞感染期间III型分泌的不同调节途径。

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  • 作者

    Lee, Vincent T.;

  • 作者单位

    University of California, Los Angeles.;

  • 授予单位 University of California, Los Angeles.;
  • 学科 Biology Microbiology.
  • 学位 Ph.D.
  • 年度 2001
  • 页码 111 p.
  • 总页数 111
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 微生物学;
  • 关键词

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