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首页> 外文学位 >Towards the Development of Phospholipid-Encapsulated Gold Nanorod Chains for Enhanced Raman-Scattering and the Improvement of Student Scientific Communication Skills in Undergraduate Classroom and Laboratory Settings
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Towards the Development of Phospholipid-Encapsulated Gold Nanorod Chains for Enhanced Raman-Scattering and the Improvement of Student Scientific Communication Skills in Undergraduate Classroom and Laboratory Settings

机译：致力于开发增强拉曼散射的磷脂包封的金纳米棒链，并提高本科生课堂和实验室环境中学生的科学交流技能

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摘要

Depending on functionalization, nanospecies can serve effectively as Surface Enhanced Raman Scattering (SERS) probes. Their efficacy can be improved by tuning their shape and concentrating their electric field profile into smaller regions. This tuning is seen particularly well in nanorods, which concentrate such fields near the rod tips or ends, in 'hotspots'. These hotspots can be constructively enhanced through the self-assembly of the nanospecies in question, further increasing the enhancement of Raman-active species within. When considering their potential application as SERS probes, both the separation of end-to-end assembled nanorods (gap size), as well as the degree of assembly (chain length), are factors that must be optimized to obtain maximal signal.;This thesis reports on the development of robust and variable methods for assembling gold nanorod species in an end-to-end configuration, and for investigating their effectiveness as SERS probes. Using both polymers and short charged ligands with control over their locations of attachment to gold nanorods, nanorod assembly could be initiated in a longitudinal direction either through changing the solvent system or through the introduction of bridging ligands. Exploitation of the inter-rod gap 'hotspot' region allowed for significant Raman enhancement of species located in said gap. Using phospholipids to encapsulate the assembling nanorod allowed for significant control over the proportions of species, in terms of length of the nanorod chain. This control allowed for further optimization of the Raman signals from species of interest.;This thesis also details the investigation, over a period of several academic years, of the success of the Writing Instruction and Training (WIT) program, an initiative to iteratively improve student written communication skills as they related to scientific chemical communication. In courses ranging from first to third year, undergraduates were provided with opportunities to explore their perceptions of scientific communication and receive extensive and formative feedback on all aspects of their submitted work, with an eye towards fostering improvement. Examining the impact both qualitatively and quantitatively revealed that such a program was highly successful in gradually building upon and expanding student knowledge of the traditions, styles, concepts and progressions of ideas so central to chemical communication.
机译：根据功能的不同，纳米物种可以有效地用作表面增强拉曼散射（SERS）探针。可以通过调整其形状并将其电场分布集中到较小区域来提高其功效。这种调整在纳米棒中尤为明显，纳米棒将这种场集中在“热点”附近的棒尖端或末端。这些热点可以通过所讨论的纳米物种的自组装来建设性地增强，从而进一步增强其中拉曼活性物种的增强。当考虑将其作为SERS探针的潜在应用时，端到端组装的纳米棒的分离（间隙尺寸）以及组装程度（链长）都是必须优化以获取最大信号的因素。论文报道了以端到端的方式组装金纳米棒物种并研究其作为SERS探针的有效性的可靠且可变的方法的发展。通过控制聚合物和短电荷配体与金纳米棒的连接位置，可以通过改变溶剂系统或引入桥连配体，在纵向方向上启动纳米棒组装。杆间间隙“热点”区域的开发允许位于所述间隙中的物种的拉曼显着增强。使用磷脂包封组装的纳米棒，就纳米棒链的长度而言，可以显着控制物种的比例。这种控制可以进一步优化来自感兴趣物种的拉曼信号。；本论文还详细介绍了在数个学年中对“写作指导与训练”（WIT）计划的成功进行的调查，该计划是一项反复改进的计划与科学化学交流相关的学生书面交流技巧。在从第一年到第三年的课程中，本科生有机会探索他们对科学交流的看法，并就提交的作品的各个方面获得广泛而形成性的反馈，以期促进进步。从定性和定量的角度考察影响，表明该计划在逐步建立和扩展学生对化学交流至关重要的传统，风格，概念和思想发展方面的知识方面非常成功。

著录项

  • 作者

    Stewart, Alexander F.;

  • 作者单位

    University of Toronto (Canada).;

  • 授予单位 University of Toronto (Canada).;
  • 学科 Nanoscience.;Pedagogy.
  • 学位 Ph.D.
  • 年度 2016
  • 页码 193 p.
  • 总页数 193
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

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